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Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods.
Int J Pharm. 2004 Mar 19; 272(1-2):1-10.IJ

Abstract

This study compares the physicochemical properties of carbamazepine (CBZ) solid dispersions prepared by either a conventional solvent evaporation versus a supercritical fluid process. Solid dispersions of carbamazepine in polyvinylpyrrolidone (PVP) K30 with either Gelucire 44/14 or Vitamin E TPGS, NF (d-alpha-tocopheryl polyethylene glycol 1000 succinate) were prepared and characterized by intrinsic dissolution, differential scanning calorimetry, powder X-ray diffraction and Fourier transform infrared spectroscopy. CBZ/PVP K30 and CBZ/PVP K30/TPGS solid dispersions showed increased dissolution rate. The best intrinsic dissolution rate (IDR) was obtained for supercritically processed CBZ/PVP K30 that was four-fold higher than pure CBZ. Thermograms of various solid dispersions did not show the melting peak of CBZ, indicating that CBZ was in amorphous form inside the carrier system. This was further confirmed by X-ray diffraction studies. Infrared spectroscopic studies showed interaction between CBZ and PVP K30 in solid dispersions. The amorphous state of CBZ coupled with presence of interaction between drug and PVP K30 suggests fewer, if any, stability problems. Because the supercritical-based process produced solid dispersions with IDR better than conventional solid dispersions augmented with amphiphilic carriers, stability issues associated with lipid carriers do not apply, which, in turn, implies easier scale up under current Good Manufacturing Practice for this technique.

Authors+Show Affiliations

College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15019063

Citation

Sethia, S, and E Squillante. "Solid Dispersion of Carbamazepine in PVP K30 By Conventional Solvent Evaporation and Supercritical Methods." International Journal of Pharmaceutics, vol. 272, no. 1-2, 2004, pp. 1-10.
Sethia S, Squillante E. Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int J Pharm. 2004;272(1-2):1-10.
Sethia, S., & Squillante, E. (2004). Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. International Journal of Pharmaceutics, 272(1-2), 1-10.
Sethia S, Squillante E. Solid Dispersion of Carbamazepine in PVP K30 By Conventional Solvent Evaporation and Supercritical Methods. Int J Pharm. 2004 Mar 19;272(1-2):1-10. PubMed PMID: 15019063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. AU - Sethia,S, AU - Squillante,E, PY - 2003/09/10/received PY - 2003/11/17/revised PY - 2003/11/17/accepted PY - 2004/3/17/pubmed PY - 2004/7/29/medline PY - 2004/3/17/entrez SP - 1 EP - 10 JF - International journal of pharmaceutics JO - Int J Pharm VL - 272 IS - 1-2 N2 - This study compares the physicochemical properties of carbamazepine (CBZ) solid dispersions prepared by either a conventional solvent evaporation versus a supercritical fluid process. Solid dispersions of carbamazepine in polyvinylpyrrolidone (PVP) K30 with either Gelucire 44/14 or Vitamin E TPGS, NF (d-alpha-tocopheryl polyethylene glycol 1000 succinate) were prepared and characterized by intrinsic dissolution, differential scanning calorimetry, powder X-ray diffraction and Fourier transform infrared spectroscopy. CBZ/PVP K30 and CBZ/PVP K30/TPGS solid dispersions showed increased dissolution rate. The best intrinsic dissolution rate (IDR) was obtained for supercritically processed CBZ/PVP K30 that was four-fold higher than pure CBZ. Thermograms of various solid dispersions did not show the melting peak of CBZ, indicating that CBZ was in amorphous form inside the carrier system. This was further confirmed by X-ray diffraction studies. Infrared spectroscopic studies showed interaction between CBZ and PVP K30 in solid dispersions. The amorphous state of CBZ coupled with presence of interaction between drug and PVP K30 suggests fewer, if any, stability problems. Because the supercritical-based process produced solid dispersions with IDR better than conventional solid dispersions augmented with amphiphilic carriers, stability issues associated with lipid carriers do not apply, which, in turn, implies easier scale up under current Good Manufacturing Practice for this technique. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/15019063/Solid_dispersion_of_carbamazepine_in_PVP_K30_by_conventional_solvent_evaporation_and_supercritical_methods_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S037851730300629X DB - PRIME DP - Unbound Medicine ER -