Prime

Type your tag names separated by a space and hit enter

Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels.

Abstract

A method was developed to prepare thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels with an interpenetrating polymer network (IPN) structure for the purpose of improving its mechanical properties, response rate to temperature and sustained release of drugs. Although the differential scanning calorimetry data exhibited similarly lower critical solution temperature (LCST) between IPN- and non-IPN-PNIPAAm hydrogels, an increase in the glass transition temperature (Tg) of the IPNs relative to the normal PNIPAAm hydrogel was observed. In addition, the mechanical properties of the IPNs were greatly improved when compared with the normal PNIPAAm hydrogel. The interior morphology of the IPN-PNIPAAm hydrogels was revealed by scanning electron microscopy (SEM); the IPN hydrogels showed a fibrillar-like porous network structure that normal PNIPAAm did not have. Furthermore, by measuring the temperature dependence of the swelling ratio and deswelling kinetics, these IPN hydrogels also exhibited improved intelligent characteristics (e.g., controllable faster response rate) that depended on the composition ratio of the two network components. From the applications viewpoint, the effects of a shrinking-reswelling cycle around the LCST on the properties of the IPN hydrogels were examined to determine if these properties would be stable for potential applications. Bovine serum albumin was chosen as the model protein for examining its release from the IPNs at different temperatures. The release data suggested that an improved controlled release could be achieved by the IPN-PNIPAAm hydrogels without losing their intelligent properties.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Textiles and Apparel and Biomedical Engineering Program, Cornell University, Ithaca, NY 14853-4401, USA.

    ,

    Source

    Biomaterials 25:17 2004 Aug pg 3793-805

    MeSH

    Absorption
    Acrylic Resins
    Biocompatible Materials
    Compressive Strength
    Delayed-Action Preparations
    Diffusion
    Drug Delivery Systems
    Hydrogels
    Kinetics
    Materials Testing
    Molecular Conformation
    Sensitivity and Specificity
    Serum Albumin, Bovine
    Surface Properties
    Temperature
    Tensile Strength
    Transition Temperature
    Water

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15020155

    Citation

    TY - JOUR T1 - Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. AU - Zhang,Xian-Zheng, AU - Wu,Da-Qing, AU - Chu,Chih-Chang, PY - 2003/05/12/received PY - 2003/10/10/accepted PY - 2004/3/17/pubmed PY - 2004/10/28/medline PY - 2004/3/17/entrez SP - 3793 EP - 805 JF - Biomaterials JO - Biomaterials VL - 25 IS - 17 N2 - A method was developed to prepare thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels with an interpenetrating polymer network (IPN) structure for the purpose of improving its mechanical properties, response rate to temperature and sustained release of drugs. Although the differential scanning calorimetry data exhibited similarly lower critical solution temperature (LCST) between IPN- and non-IPN-PNIPAAm hydrogels, an increase in the glass transition temperature (Tg) of the IPNs relative to the normal PNIPAAm hydrogel was observed. In addition, the mechanical properties of the IPNs were greatly improved when compared with the normal PNIPAAm hydrogel. The interior morphology of the IPN-PNIPAAm hydrogels was revealed by scanning electron microscopy (SEM); the IPN hydrogels showed a fibrillar-like porous network structure that normal PNIPAAm did not have. Furthermore, by measuring the temperature dependence of the swelling ratio and deswelling kinetics, these IPN hydrogels also exhibited improved intelligent characteristics (e.g., controllable faster response rate) that depended on the composition ratio of the two network components. From the applications viewpoint, the effects of a shrinking-reswelling cycle around the LCST on the properties of the IPN hydrogels were examined to determine if these properties would be stable for potential applications. Bovine serum albumin was chosen as the model protein for examining its release from the IPNs at different temperatures. The release data suggested that an improved controlled release could be achieved by the IPN-PNIPAAm hydrogels without losing their intelligent properties. SN - 0142-9612 UR - https://www.unboundmedicine.com/medline/citation/15020155/Synthesis_characterization_and_controlled_drug_release_of_thermosensitive_IPN_PNIPAAm_hydrogels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0142961203009955 ER -