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TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps.
Int J Epidemiol 2004; 33(5):955-61IJ

Abstract

BACKGROUND

Transforming growth factor-beta1 (TGFbeta1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGFbeta1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of those growths that do develop. A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele.

METHODS

We investigated whether this polymorphism was associated with the risk of colorectal adenomatous or hyperplastic polyps in a case-control study of individuals from Minnesota. Risk of colorectal polyps was evaluated separately for individuals with adenomatous polyps (n = 513) and hyperplastic polyps (n = 191) relative to polyp-free controls (n = 606) using logistic regression analysis.

RESULTS

No overall association was seen between the L10P polymorphism and risk of colorectal adenomatous polyps. The age- and sex-adjusted odds ratios (OR) of developing colorectal hyperplastic polyps were 1.0 (95% CI: 0.7, 1.4) and 0.7 (95% CI: 0.4, 1.1) for individuals with the LP and PP genotypes, respectively, compared with individuals with the LL genotype. When stratified by smoking, evidence for a decreased risk of hyperplastic polyps associated with the P allele was seen only among ever smokers (P for trend = 0.05).

CONCLUSIONS

Whereas adenoma risk did not vary by TGFbeta1 L10P genotype, these results suggest that the L10P variant allele may have a protective role in the development of colorectal hyperplastic polyps, possibly consistent with its role as an inhibitor of epithelial growths.

Authors+Show Affiliations

Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15020570

Citation

Sparks, Rachel, et al. "TGFbeta1 Polymorphism (L10P) and Risk of Colorectal Adenomatous and Hyperplastic Polyps." International Journal of Epidemiology, vol. 33, no. 5, 2004, pp. 955-61.
Sparks R, Bigler J, Sibert JG, et al. TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps. Int J Epidemiol. 2004;33(5):955-61.
Sparks, R., Bigler, J., Sibert, J. G., Potter, J. D., Yasui, Y., & Ulrich, C. M. (2004). TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps. International Journal of Epidemiology, 33(5), pp. 955-61.
Sparks R, et al. TGFbeta1 Polymorphism (L10P) and Risk of Colorectal Adenomatous and Hyperplastic Polyps. Int J Epidemiol. 2004;33(5):955-61. PubMed PMID: 15020570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps. AU - Sparks,Rachel, AU - Bigler,Jeannette, AU - Sibert,Justin G, AU - Potter,John D, AU - Yasui,Yutaka, AU - Ulrich,Cornelia M, Y1 - 2004/03/11/ PY - 2004/3/17/pubmed PY - 2004/12/17/medline PY - 2004/3/17/entrez SP - 955 EP - 61 JF - International journal of epidemiology JO - Int J Epidemiol VL - 33 IS - 5 N2 - BACKGROUND: Transforming growth factor-beta1 (TGFbeta1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGFbeta1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of those growths that do develop. A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele. METHODS: We investigated whether this polymorphism was associated with the risk of colorectal adenomatous or hyperplastic polyps in a case-control study of individuals from Minnesota. Risk of colorectal polyps was evaluated separately for individuals with adenomatous polyps (n = 513) and hyperplastic polyps (n = 191) relative to polyp-free controls (n = 606) using logistic regression analysis. RESULTS: No overall association was seen between the L10P polymorphism and risk of colorectal adenomatous polyps. The age- and sex-adjusted odds ratios (OR) of developing colorectal hyperplastic polyps were 1.0 (95% CI: 0.7, 1.4) and 0.7 (95% CI: 0.4, 1.1) for individuals with the LP and PP genotypes, respectively, compared with individuals with the LL genotype. When stratified by smoking, evidence for a decreased risk of hyperplastic polyps associated with the P allele was seen only among ever smokers (P for trend = 0.05). CONCLUSIONS: Whereas adenoma risk did not vary by TGFbeta1 L10P genotype, these results suggest that the L10P variant allele may have a protective role in the development of colorectal hyperplastic polyps, possibly consistent with its role as an inhibitor of epithelial growths. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/15020570/TGFbeta1_polymorphism__L10P__and_risk_of_colorectal_adenomatous_and_hyperplastic_polyps_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyh102 DB - PRIME DP - Unbound Medicine ER -