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Zoonotic poxvirus infections in humans.
Curr Opin Infect Dis 2004; 17(2):81-9CO

Abstract

PURPOSE OF REVIEW

The 2003 USA monkeypox epidemic caused by imported African rodents, newly emergent poxvirus zoonoses in Brazil and the possible use of variola virus for biological warfare has led to renewed interest in poxviruses and anti-poxviral therapies. Increasing foreign travel and importation of exotic animal species increases the likelihood of poxvirus infections occurring outside their usual geographical range and diagnostic delay has important implications. The present review provides an overview of these rare zoonoses.

RECENT FINDINGS

Three genera of Poxviridae are known to cause human zoonoses: orthopoxviruses, parapoxviruses and yatapoxvirus. Most cases are occupational, sporadic and have few cutaneous lesions with low morbidity. The exception is monkeypox, similar to smallpox, with significant morbidity and childhood mortality. Molecular characterization using polymerase chain reaction (PCR) amplification and other methods provides accurate phylogenetic identification and suggests that a cowpox-like virus is the probable ancestor of variola and other zoonotic poxviruses. DNA genomic sequencing of the Brazilian Cantagalo and Araçatuba viruses shows a close relationship to vaccinia virus. Poxviruses have potential in cancer immunotherapy and their ability to evade host-cell immune responses may provide a basis for new antipoxvirus therapies. Other agents, particularly nucleoside phosphonates such as cidofovir, show therapeutic action against poxviruses.

SUMMARY

Human zoonotic poxvirus infections are rare but increasingly encountered outside their usual geographical range. The 2003 USA monkeypox outbreak emphasizes the importance of early accurate diagnosis, particularly because increasing numbers of immunosuppressed individuals increases the potential for severe or fatal infections. PCR methodology enables accurate phylogenetic typing and has identified new diseases, but rapid, reliable methods must be made available for clinicians. More research into therapeutic agents for the prevention and treatment of poxvirus infections is required.

Authors+Show Affiliations

Department of Dermatology, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15021045

Citation

Lewis-Jones, Sue. "Zoonotic Poxvirus Infections in Humans." Current Opinion in Infectious Diseases, vol. 17, no. 2, 2004, pp. 81-9.
Lewis-Jones S. Zoonotic poxvirus infections in humans. Curr Opin Infect Dis. 2004;17(2):81-9.
Lewis-Jones, S. (2004). Zoonotic poxvirus infections in humans. Current Opinion in Infectious Diseases, 17(2), pp. 81-9.
Lewis-Jones S. Zoonotic Poxvirus Infections in Humans. Curr Opin Infect Dis. 2004;17(2):81-9. PubMed PMID: 15021045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zoonotic poxvirus infections in humans. A1 - Lewis-Jones,Sue, PY - 2004/3/17/pubmed PY - 2004/5/28/medline PY - 2004/3/17/entrez SP - 81 EP - 9 JF - Current opinion in infectious diseases JO - Curr. Opin. Infect. Dis. VL - 17 IS - 2 N2 - PURPOSE OF REVIEW: The 2003 USA monkeypox epidemic caused by imported African rodents, newly emergent poxvirus zoonoses in Brazil and the possible use of variola virus for biological warfare has led to renewed interest in poxviruses and anti-poxviral therapies. Increasing foreign travel and importation of exotic animal species increases the likelihood of poxvirus infections occurring outside their usual geographical range and diagnostic delay has important implications. The present review provides an overview of these rare zoonoses. RECENT FINDINGS: Three genera of Poxviridae are known to cause human zoonoses: orthopoxviruses, parapoxviruses and yatapoxvirus. Most cases are occupational, sporadic and have few cutaneous lesions with low morbidity. The exception is monkeypox, similar to smallpox, with significant morbidity and childhood mortality. Molecular characterization using polymerase chain reaction (PCR) amplification and other methods provides accurate phylogenetic identification and suggests that a cowpox-like virus is the probable ancestor of variola and other zoonotic poxviruses. DNA genomic sequencing of the Brazilian Cantagalo and Araçatuba viruses shows a close relationship to vaccinia virus. Poxviruses have potential in cancer immunotherapy and their ability to evade host-cell immune responses may provide a basis for new antipoxvirus therapies. Other agents, particularly nucleoside phosphonates such as cidofovir, show therapeutic action against poxviruses. SUMMARY: Human zoonotic poxvirus infections are rare but increasingly encountered outside their usual geographical range. The 2003 USA monkeypox outbreak emphasizes the importance of early accurate diagnosis, particularly because increasing numbers of immunosuppressed individuals increases the potential for severe or fatal infections. PCR methodology enables accurate phylogenetic typing and has identified new diseases, but rapid, reliable methods must be made available for clinicians. More research into therapeutic agents for the prevention and treatment of poxvirus infections is required. SN - 0951-7375 UR - https://www.unboundmedicine.com/medline/citation/15021045/Zoonotic_poxvirus_infections_in_humans_ L2 - http://Insights.ovid.com/pubmed?pmid=15021045 DB - PRIME DP - Unbound Medicine ER -