Tags

Type your tag names separated by a space and hit enter

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.
Phytother Res 2004; 18(2):107-10PR

Abstract

Silymarin, an extract of fl avonolignans from the dried fruits of milk thistle (Silybum marianum L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were tested for protective effects on rat cardiomyocytes exposed to doxorubicin. Silymarin and individual fl avonolignans did not exert cytotoxicity in the range 25-100 micro m (incubation 9 h). Dehydrosilibinin was tested only at 25 micro m concentration due to its low solubility. All substances increased the cell ATP level. Silymarin and fl avonolignans displayed a dose-dependent cytoprotection against doxorubicin (100 micro m, incubation 8 h). The protective effects of silymarin, silibinin, dehydrosilibinin and silychristin were comparable to that of dexrasoxane, while silydianin exerted the best protective effect. The ability of silymarin complex and its components to protect cardiomyocytes against doxorubicin-induced oxidative stress is due mainly to their cell membrane stabilization effect, radical scavenging and iron chelating potency.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Hnevotínská 3, 775 15 Olomouc, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15022159

Citation

Chlopcíková, Sárka, et al. "Chemoprotective Effect of Plant Phenolics Against Anthracycline-induced Toxicity On Rat Cardiomyocytes. Part I. Silymarin and Its Flavonolignans." Phytotherapy Research : PTR, vol. 18, no. 2, 2004, pp. 107-10.
Chlopcíková S, Psotová J, Miketová P, et al. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans. Phytother Res. 2004;18(2):107-10.
Chlopcíková, S., Psotová, J., Miketová, P., & Simánek, V. (2004). Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans. Phytotherapy Research : PTR, 18(2), pp. 107-10.
Chlopcíková S, et al. Chemoprotective Effect of Plant Phenolics Against Anthracycline-induced Toxicity On Rat Cardiomyocytes. Part I. Silymarin and Its Flavonolignans. Phytother Res. 2004;18(2):107-10. PubMed PMID: 15022159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans. AU - Chlopcíková,Sárka, AU - Psotová,Jitka, AU - Miketová,Petra, AU - Simánek,Vilím, PY - 2004/3/17/pubmed PY - 2004/5/14/medline PY - 2004/3/17/entrez SP - 107 EP - 10 JF - Phytotherapy research : PTR JO - Phytother Res VL - 18 IS - 2 N2 - Silymarin, an extract of fl avonolignans from the dried fruits of milk thistle (Silybum marianum L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were tested for protective effects on rat cardiomyocytes exposed to doxorubicin. Silymarin and individual fl avonolignans did not exert cytotoxicity in the range 25-100 micro m (incubation 9 h). Dehydrosilibinin was tested only at 25 micro m concentration due to its low solubility. All substances increased the cell ATP level. Silymarin and fl avonolignans displayed a dose-dependent cytoprotection against doxorubicin (100 micro m, incubation 8 h). The protective effects of silymarin, silibinin, dehydrosilibinin and silychristin were comparable to that of dexrasoxane, while silydianin exerted the best protective effect. The ability of silymarin complex and its components to protect cardiomyocytes against doxorubicin-induced oxidative stress is due mainly to their cell membrane stabilization effect, radical scavenging and iron chelating potency. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/15022159/Chemoprotective_effect_of_plant_phenolics_against_anthracycline_induced_toxicity_on_rat_cardiomyocytes__Part_I__Silymarin_and_its_flavonolignans_ L2 - https://doi.org/10.1002/ptr.1415 DB - PRIME DP - Unbound Medicine ER -