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Modified guar gum matrix tablet for controlled release of diltiazem hydrochloride.
J Control Release. 2004 Mar 24; 95(3):567-77.JC

Abstract

Polyacrylamide-grafted-guar gum (pAAm-g-GG) was prepared by taking three different ratios of guar gum to acrylamide (1:2, 1:3.5 and 1:5). Amide groups of these grafted copolymers were converted into carboxylic functional groups. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry were used to characterize copolymers. Tablets were prepared by incorporating an antihypertensive drug viz., diltiazem hydrochloride. In-vitro drug release was carried out in simulated gastric and intestinal conditions. Effect of drug loading on release kinetics was evaluated. Release continued up to 8 and 12 h, respectively, for pAAm-g-GG and hydrolyzed pAAm-g-GG copolymers. Nature of drug transport through the polymer matrices was studied by comparing with Higuchi, Hixson-Crowell and Kopcha equations. Drug release was found to be dissolution-controlled in case of unhydrolyzed copolymer. With hydrolyzed copolymers, drug release was swelling-controlled initially (i.e., in 0.1 N HCl), but at later stage, it became dissolution-controlled in pH 7.4. Hydrolyzed pAAm-g-GG matrices are pH sensitive and can be used for intestinal drug delivery.

Authors+Show Affiliations

Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad-580 003, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15023467

Citation

Toti, Udaya S., and Tejraj M. Aminabhavi. "Modified Guar Gum Matrix Tablet for Controlled Release of Diltiazem Hydrochloride." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 95, no. 3, 2004, pp. 567-77.
Toti US, Aminabhavi TM. Modified guar gum matrix tablet for controlled release of diltiazem hydrochloride. J Control Release. 2004;95(3):567-77.
Toti, U. S., & Aminabhavi, T. M. (2004). Modified guar gum matrix tablet for controlled release of diltiazem hydrochloride. Journal of Controlled Release : Official Journal of the Controlled Release Society, 95(3), 567-77.
Toti US, Aminabhavi TM. Modified Guar Gum Matrix Tablet for Controlled Release of Diltiazem Hydrochloride. J Control Release. 2004 Mar 24;95(3):567-77. PubMed PMID: 15023467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modified guar gum matrix tablet for controlled release of diltiazem hydrochloride. AU - Toti,Udaya S, AU - Aminabhavi,Tejraj M, PY - 2003/09/24/received PY - 2003/12/25/accepted PY - 2004/3/17/pubmed PY - 2005/1/15/medline PY - 2004/3/17/entrez SP - 567 EP - 77 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 95 IS - 3 N2 - Polyacrylamide-grafted-guar gum (pAAm-g-GG) was prepared by taking three different ratios of guar gum to acrylamide (1:2, 1:3.5 and 1:5). Amide groups of these grafted copolymers were converted into carboxylic functional groups. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry were used to characterize copolymers. Tablets were prepared by incorporating an antihypertensive drug viz., diltiazem hydrochloride. In-vitro drug release was carried out in simulated gastric and intestinal conditions. Effect of drug loading on release kinetics was evaluated. Release continued up to 8 and 12 h, respectively, for pAAm-g-GG and hydrolyzed pAAm-g-GG copolymers. Nature of drug transport through the polymer matrices was studied by comparing with Higuchi, Hixson-Crowell and Kopcha equations. Drug release was found to be dissolution-controlled in case of unhydrolyzed copolymer. With hydrolyzed copolymers, drug release was swelling-controlled initially (i.e., in 0.1 N HCl), but at later stage, it became dissolution-controlled in pH 7.4. Hydrolyzed pAAm-g-GG matrices are pH sensitive and can be used for intestinal drug delivery. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/15023467/Modified_guar_gum_matrix_tablet_for_controlled_release_of_diltiazem_hydrochloride_ DB - PRIME DP - Unbound Medicine ER -