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Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy.
Biol Psychiatry. 2004 Mar 01; 55(5):538-45.BP

Abstract

BACKGROUND

Hippocampal volume reduction, declarative memory deficits, and cortisol elevations are reported in persons with major depressive disorder; however, data linking cortisol elevations with hippocampal atrophy are lacking. Prescription corticosteroid-treated patients offer an opportunity to examine corticosteroid effects on hippocampal volume and biochemistry and memory in humans.

METHODS

Seventeen patients on long-term prescription corticosteroid therapy and 15 controls of similar age, gender, ethnicity, education, height, and medical history were assessed with magnetic resonance imaging and proton magnetic resonance spectroscopy, the Rey Auditory Verbal Learning Test, Stroop Color Word Test and other neurocognitive measures, the Hamilton Rating Scale for Depression, Young Mania Rating Scale, and Brief Psychiatric Rating Scale.

RESULTS

Compared with controls, corticosteroid-treated patients had smaller hippocampal volumes and lower N-acetyl aspartate ratios, lower scores on the Rey Auditory Verbal Learning Test and Stroop Color Word Test, and higher Hamilton Rating Scale for Depression and Brief Psychiatric Rating Scale scores.

CONCLUSIONS

Patients receiving chronic corticosteroid therapy have smaller hippocampal volumes, lower N-acetyl aspartate ratios, and declarative memory deficits compared with controls. These findings support the idea that corticosteroid exposure appears to be associated with changes in hippocampal volume and functioning in humans.

Authors+Show Affiliations

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8849, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15023583

Citation

Brown, E Sherwood, et al. "Hippocampal Volume, Spectroscopy, Cognition, and Mood in Patients Receiving Corticosteroid Therapy." Biological Psychiatry, vol. 55, no. 5, 2004, pp. 538-45.
Brown ES, J Woolston D, Frol A, et al. Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. Biol Psychiatry. 2004;55(5):538-45.
Brown, E. S., J Woolston, D., Frol, A., Bobadilla, L., Khan, D. A., Hanczyc, M., Rush, A. J., Fleckenstein, J., Babcock, E., & Cullum, C. M. (2004). Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. Biological Psychiatry, 55(5), 538-45.
Brown ES, et al. Hippocampal Volume, Spectroscopy, Cognition, and Mood in Patients Receiving Corticosteroid Therapy. Biol Psychiatry. 2004 Mar 1;55(5):538-45. PubMed PMID: 15023583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. AU - Brown,E Sherwood, AU - J Woolston,Dixie, AU - Frol,Alan, AU - Bobadilla,Leonardo, AU - Khan,David A, AU - Hanczyc,Margaret, AU - Rush,A John, AU - Fleckenstein,James, AU - Babcock,Evelyn, AU - Cullum,C Munro, PY - 2003/06/27/received PY - 2003/09/19/revised PY - 2003/09/24/accepted PY - 2004/3/17/pubmed PY - 2004/5/28/medline PY - 2004/3/17/entrez SP - 538 EP - 45 JF - Biological psychiatry JO - Biol. Psychiatry VL - 55 IS - 5 N2 - BACKGROUND: Hippocampal volume reduction, declarative memory deficits, and cortisol elevations are reported in persons with major depressive disorder; however, data linking cortisol elevations with hippocampal atrophy are lacking. Prescription corticosteroid-treated patients offer an opportunity to examine corticosteroid effects on hippocampal volume and biochemistry and memory in humans. METHODS: Seventeen patients on long-term prescription corticosteroid therapy and 15 controls of similar age, gender, ethnicity, education, height, and medical history were assessed with magnetic resonance imaging and proton magnetic resonance spectroscopy, the Rey Auditory Verbal Learning Test, Stroop Color Word Test and other neurocognitive measures, the Hamilton Rating Scale for Depression, Young Mania Rating Scale, and Brief Psychiatric Rating Scale. RESULTS: Compared with controls, corticosteroid-treated patients had smaller hippocampal volumes and lower N-acetyl aspartate ratios, lower scores on the Rey Auditory Verbal Learning Test and Stroop Color Word Test, and higher Hamilton Rating Scale for Depression and Brief Psychiatric Rating Scale scores. CONCLUSIONS: Patients receiving chronic corticosteroid therapy have smaller hippocampal volumes, lower N-acetyl aspartate ratios, and declarative memory deficits compared with controls. These findings support the idea that corticosteroid exposure appears to be associated with changes in hippocampal volume and functioning in humans. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/15023583/Hippocampal_volume_spectroscopy_cognition_and_mood_in_patients_receiving_corticosteroid_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006322303010412 DB - PRIME DP - Unbound Medicine ER -