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Effect of cisapride on relapse of reflux oesophagitis, healed with an antisecretory drug.
Scand J Gastroenterol. 1992; 27(3):175-83.SJ

Abstract

Maintenance treatment with cisapride was evaluated in 298 patients in whom reflux oesophagitis had been healed with antisecretory drugs. Initially, 34% of the patients had grade-I oesophagitis, 33% had grade II, and 33% had grade III. The patients were treated with 20 mg cisapride twice daily or placebo for 6 months or until endoscopic relapse was shown if this occurred earlier. Survival analysis showed that cisapride significantly prolonged the time to endoscopic relapse in grade-I patients (P = 0.02). The intergroup difference in symptomatic relapse in all patients was also significant (P = 0.010). The effect of cisapride was less clearcut in grade II or III, and/or in patients healed with omeprazole. Factors associated with early relapse were placebo therapy, prior omeprazole therapy, duration of pre-trial symptomatic period, and initial endoscopic severity grade. Adverse experiences were limited; diarrhoea was reported by 9% of the cisapride patients.

Authors+Show Affiliations

Dept. of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1502478

Citation

Tytgat, G N., et al. "Effect of Cisapride On Relapse of Reflux Oesophagitis, Healed With an Antisecretory Drug." Scandinavian Journal of Gastroenterology, vol. 27, no. 3, 1992, pp. 175-83.
Tytgat GN, Anker Hansen OJ, Carling L, et al. Effect of cisapride on relapse of reflux oesophagitis, healed with an antisecretory drug. Scand J Gastroenterol. 1992;27(3):175-83.
Tytgat, G. N., Anker Hansen, O. J., Carling, L., de Groot, G. H., Geldof, H., Glise, H., Efskind, P., Elsborg, L., Karvonen, A. L., & Ohlin, B. (1992). Effect of cisapride on relapse of reflux oesophagitis, healed with an antisecretory drug. Scandinavian Journal of Gastroenterology, 27(3), 175-83.
Tytgat GN, et al. Effect of Cisapride On Relapse of Reflux Oesophagitis, Healed With an Antisecretory Drug. Scand J Gastroenterol. 1992;27(3):175-83. PubMed PMID: 1502478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cisapride on relapse of reflux oesophagitis, healed with an antisecretory drug. A1 - Tytgat,G N, AU - Anker Hansen,O J, AU - Carling,L, AU - de Groot,G H, AU - Geldof,H, AU - Glise,H, AU - Efskind,P, AU - Elsborg,L, AU - Karvonen,A L, AU - Ohlin,B, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 175 EP - 83 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 27 IS - 3 N2 - Maintenance treatment with cisapride was evaluated in 298 patients in whom reflux oesophagitis had been healed with antisecretory drugs. Initially, 34% of the patients had grade-I oesophagitis, 33% had grade II, and 33% had grade III. The patients were treated with 20 mg cisapride twice daily or placebo for 6 months or until endoscopic relapse was shown if this occurred earlier. Survival analysis showed that cisapride significantly prolonged the time to endoscopic relapse in grade-I patients (P = 0.02). The intergroup difference in symptomatic relapse in all patients was also significant (P = 0.010). The effect of cisapride was less clearcut in grade II or III, and/or in patients healed with omeprazole. Factors associated with early relapse were placebo therapy, prior omeprazole therapy, duration of pre-trial symptomatic period, and initial endoscopic severity grade. Adverse experiences were limited; diarrhoea was reported by 9% of the cisapride patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/1502478/Effect_of_cisapride_on_relapse_of_reflux_oesophagitis_healed_with_an_antisecretory_drug_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365529208999945 DB - PRIME DP - Unbound Medicine ER -