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Study of haemoglobin S percentage and haematological parameters in sickle cell trait.
Indian J Pathol Microbiol. 2003 Jul; 46(3):420-4.IJ

Abstract

A total of 101 individuals who showed AS pattern on haemoglobin electrophoresis were included in this study and various haematological investigations were carried out on them. Of these, 79 cases were grouped as AS patients. Twenty two healthy relatives of sickle anemia patients were grouped as AS controls. Twenty AA controls were also included in this study. Haemoglobin S (HbS) and hemoglobin A (HbA) quantitation was carried out. The frequency distribution of HbS percentage showed that maximum subjects had HbS levels above 33%. A female predominance was seen in subjects of sickle cell trait. Haemoglobin levels and total red cell counts of AS patients were found to be significantly lower than those of AS controls. Reticulocyte counts and hematocrit values of AS patients were found to be significantly higher than AS controls. MCV and MCH values of AS patients were found to be significantly lower, but MCHC was not significantly altered.

Authors+Show Affiliations

Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442102 Wardha (Maharashtra).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15025289

Citation

Pathak, Kiran, et al. "Study of Haemoglobin S Percentage and Haematological Parameters in Sickle Cell Trait." Indian Journal of Pathology & Microbiology, vol. 46, no. 3, 2003, pp. 420-4.
Pathak K, Kishore S, Anshu , et al. Study of haemoglobin S percentage and haematological parameters in sickle cell trait. Indian J Pathol Microbiol. 2003;46(3):420-4.
Pathak, K., Kishore, S., Anshu, ., Shivkumar, V. B., Gangane, N., & Sharma, S. (2003). Study of haemoglobin S percentage and haematological parameters in sickle cell trait. Indian Journal of Pathology & Microbiology, 46(3), 420-4.
Pathak K, et al. Study of Haemoglobin S Percentage and Haematological Parameters in Sickle Cell Trait. Indian J Pathol Microbiol. 2003;46(3):420-4. PubMed PMID: 15025289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of haemoglobin S percentage and haematological parameters in sickle cell trait. AU - Pathak,Kiran, AU - Kishore,Sanjeev, AU - Anshu,, AU - Shivkumar,V B, AU - Gangane,Nitin, AU - Sharma,Satish, PY - 2004/3/18/pubmed PY - 2004/5/1/medline PY - 2004/3/18/entrez SP - 420 EP - 4 JF - Indian journal of pathology & microbiology JO - Indian J Pathol Microbiol VL - 46 IS - 3 N2 - A total of 101 individuals who showed AS pattern on haemoglobin electrophoresis were included in this study and various haematological investigations were carried out on them. Of these, 79 cases were grouped as AS patients. Twenty two healthy relatives of sickle anemia patients were grouped as AS controls. Twenty AA controls were also included in this study. Haemoglobin S (HbS) and hemoglobin A (HbA) quantitation was carried out. The frequency distribution of HbS percentage showed that maximum subjects had HbS levels above 33%. A female predominance was seen in subjects of sickle cell trait. Haemoglobin levels and total red cell counts of AS patients were found to be significantly lower than those of AS controls. Reticulocyte counts and hematocrit values of AS patients were found to be significantly higher than AS controls. MCV and MCH values of AS patients were found to be significantly lower, but MCHC was not significantly altered. SN - 0377-4929 UR - https://www.unboundmedicine.com/medline/citation/15025289/Study_of_haemoglobin_S_percentage_and_haematological_parameters_in_sickle_cell_trait_ L2 - http://www.diseaseinfosearch.org/result/6591 DB - PRIME DP - Unbound Medicine ER -