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Is bone mineral density predictive of fracture risk reduction?
Curr Med Res Opin. 2004 Mar; 20(3):341-9.CM

Abstract

Bone mineral density (BMD) measurement is a widely available noninvasive means of identifying individuals with osteoporosis and, possibly, those at high risk for fracture. This nonsystematic review examines the relationship between BMD increase and fracture risk reduction in clinical trials evaluating osteoporosis therapy. The trials examined here are predominantly in postmenopausal women. BMD increase correlates poorly with fracture risk reduction in clinical trials of osteoporosis therapy conducted in postmenopausal women. Although BMD may increase with therapy, the increase is not measurable until later, and the overall increase is too small to account for the timing and magnitude of fracture risk reduction. BMD is only one of many contributors to bone strength and fracture risk reduction. Bone strength is derived from bone quantity, which consists of density and size, and bone quality, which, in turn, consists of structure (micro- and macroarchitecture), material properties, and turnover. Data are beginning to accrue suggesting that changes in bone turnover markers may be an accurate predictor of fracture risk reduction. Future research will elucidate the link between changes in bone turnover markers and bone architecture as a measure of osteoporosis treatment efficacy. Until then, physicians will continue to rely on fracture risk reduction data from well-designed clinical trials when judging the efficacy of different treatments for osteoporosis.

Authors+Show Affiliations

Department of Family Medicine, Louisiana State University Medical Center, New Orleans, LA 70112, USA. ccefal@lsuhsc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15025843

Citation

Cefalu, Charles A.. "Is Bone Mineral Density Predictive of Fracture Risk Reduction?" Current Medical Research and Opinion, vol. 20, no. 3, 2004, pp. 341-9.
Cefalu CA. Is bone mineral density predictive of fracture risk reduction? Curr Med Res Opin. 2004;20(3):341-9.
Cefalu, C. A. (2004). Is bone mineral density predictive of fracture risk reduction? Current Medical Research and Opinion, 20(3), 341-9.
Cefalu CA. Is Bone Mineral Density Predictive of Fracture Risk Reduction. Curr Med Res Opin. 2004;20(3):341-9. PubMed PMID: 15025843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is bone mineral density predictive of fracture risk reduction? A1 - Cefalu,Charles A, PY - 2004/3/18/pubmed PY - 2004/6/21/medline PY - 2004/3/18/entrez SP - 341 EP - 9 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 20 IS - 3 N2 - Bone mineral density (BMD) measurement is a widely available noninvasive means of identifying individuals with osteoporosis and, possibly, those at high risk for fracture. This nonsystematic review examines the relationship between BMD increase and fracture risk reduction in clinical trials evaluating osteoporosis therapy. The trials examined here are predominantly in postmenopausal women. BMD increase correlates poorly with fracture risk reduction in clinical trials of osteoporosis therapy conducted in postmenopausal women. Although BMD may increase with therapy, the increase is not measurable until later, and the overall increase is too small to account for the timing and magnitude of fracture risk reduction. BMD is only one of many contributors to bone strength and fracture risk reduction. Bone strength is derived from bone quantity, which consists of density and size, and bone quality, which, in turn, consists of structure (micro- and macroarchitecture), material properties, and turnover. Data are beginning to accrue suggesting that changes in bone turnover markers may be an accurate predictor of fracture risk reduction. Future research will elucidate the link between changes in bone turnover markers and bone architecture as a measure of osteoporosis treatment efficacy. Until then, physicians will continue to rely on fracture risk reduction data from well-designed clinical trials when judging the efficacy of different treatments for osteoporosis. SN - 0300-7995 UR - https://www.unboundmedicine.com/medline/citation/15025843/Is_bone_mineral_density_predictive_of_fracture_risk_reduction L2 - https://www.tandfonline.com/doi/full/10.1185/030079903125003062 DB - PRIME DP - Unbound Medicine ER -