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Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase.
Mol Cell Endocrinol. 2004 Feb 27; 215(1-2):31-8.MC

Abstract

Much recent attention has focused on the positive health benefits of vitamin D beyond its established role in calcium homeostasis. Epidemiology has highlighted the link between vitamin D deficiency and prevalent diseases such as common cancers and autoimmune disease. Furthermore, studies in vitro have shown that the active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is a potent antiproliferative and immunosuppressive agent. The net effect of this has been the generation and analysis of synthetic analogues of vitamin D for potential use in the treatment of cancers and other disorders including psoriasis. However, there is increasing interest in the impact that vitamin D may have on normal physiology above and beyond its classical effects on calcium homeostasis and bone metabolism. We have postulated that these 'non-calcemic' effects of vitamin D are dependent on extra-renal synthesis of 1,25(OH)(2)D(3) via the enzyme 1 alpha-hydroxylase at barrier sites throughout the body. Here we present a review of the mechanisms associated with extra-renal 1 alpha-hydroxylase, and we also speculate on how this 'new' physiological role for vitamin D may actually reflect an ancient function for this pluripotent secosteroid.

Authors+Show Affiliations

Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK. m.hewison@bham.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15026172

Citation

Hewison, Martin, et al. "Vitamin D and Barrier Function: a Novel Role for Extra-renal 1 Alpha-hydroxylase." Molecular and Cellular Endocrinology, vol. 215, no. 1-2, 2004, pp. 31-8.
Hewison M, Zehnder D, Chakraverty R, et al. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol. 2004;215(1-2):31-8.
Hewison, M., Zehnder, D., Chakraverty, R., & Adams, J. S. (2004). Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Molecular and Cellular Endocrinology, 215(1-2), 31-8.
Hewison M, et al. Vitamin D and Barrier Function: a Novel Role for Extra-renal 1 Alpha-hydroxylase. Mol Cell Endocrinol. 2004 Feb 27;215(1-2):31-8. PubMed PMID: 15026172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. AU - Hewison,Martin, AU - Zehnder,Daniel, AU - Chakraverty,Ronjon, AU - Adams,John S, PY - 2004/3/18/pubmed PY - 2004/10/22/medline PY - 2004/3/18/entrez SP - 31 EP - 8 JF - Molecular and cellular endocrinology JO - Mol. Cell. Endocrinol. VL - 215 IS - 1-2 N2 - Much recent attention has focused on the positive health benefits of vitamin D beyond its established role in calcium homeostasis. Epidemiology has highlighted the link between vitamin D deficiency and prevalent diseases such as common cancers and autoimmune disease. Furthermore, studies in vitro have shown that the active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is a potent antiproliferative and immunosuppressive agent. The net effect of this has been the generation and analysis of synthetic analogues of vitamin D for potential use in the treatment of cancers and other disorders including psoriasis. However, there is increasing interest in the impact that vitamin D may have on normal physiology above and beyond its classical effects on calcium homeostasis and bone metabolism. We have postulated that these 'non-calcemic' effects of vitamin D are dependent on extra-renal synthesis of 1,25(OH)(2)D(3) via the enzyme 1 alpha-hydroxylase at barrier sites throughout the body. Here we present a review of the mechanisms associated with extra-renal 1 alpha-hydroxylase, and we also speculate on how this 'new' physiological role for vitamin D may actually reflect an ancient function for this pluripotent secosteroid. SN - 0303-7207 UR - https://www.unboundmedicine.com/medline/citation/15026172/Vitamin_D_and_barrier_function:_a_novel_role_for_extra_renal_1_alpha_hydroxylase_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303720703005008 DB - PRIME DP - Unbound Medicine ER -