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Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir.

Abstract

Human influenza viruses isolated from Australasia (Australia and New Zealand) and South East Asia were analysed to determine their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir. A total of 532 strains isolated between 1998 and 2002 were tested using a fluorescence-based assay to measure the relative inhibition of NA activity over a range of drug concentrations. Based on median IC50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influenza B strains. Influenza A viruses with a N1 subtype and influenza B strains both demonstrated a greater sensitivity to zanamivir than to oseltamivir carboxylate, whereas influenza A strains with a N2 subtype were more susceptible to oseltamivir carboxylate. For each of the neuraminidase types, IC50 values for viruses from Australasia and South East Asia were found to be comparable. Based on the data prior to and following the licensing of the drugs into the respective regions, the use of the NA inhibitors did not appear to have a significant impact on the susceptibility of the viruses tested to zanamivir or oseltamivir carboxylate.

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  • Authors+Show Affiliations

    ,

    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Vic. 3052, Australia. Aeron_Hurt@csl.com.au

    , ,

    Source

    Antiviral research 62:1 2004 Apr pg 37-45

    MeSH

    Acetamides
    Antiviral Agents
    Asia, Southeastern
    Australasia
    Drug Resistance, Viral
    Fluorescence
    Guanidines
    Humans
    Hymecromone
    Influenza A virus
    Influenza B virus
    Microbial Sensitivity Tests
    Neuraminidase
    Orthomyxoviridae
    Oseltamivir
    Pyrans
    Sialic Acids
    Viral Proteins
    Zanamivir

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15026200

    Citation

    Hurt, Aeron C., et al. "Susceptibility of Human Influenza Viruses From Australasia and South East Asia to the Neuraminidase Inhibitors Zanamivir and Oseltamivir." Antiviral Research, vol. 62, no. 1, 2004, pp. 37-45.
    Hurt AC, Barr IG, Hartel G, et al. Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir. Antiviral Res. 2004;62(1):37-45.
    Hurt, A. C., Barr, I. G., Hartel, G., & Hampson, A. W. (2004). Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir. Antiviral Research, 62(1), pp. 37-45.
    Hurt AC, et al. Susceptibility of Human Influenza Viruses From Australasia and South East Asia to the Neuraminidase Inhibitors Zanamivir and Oseltamivir. Antiviral Res. 2004;62(1):37-45. PubMed PMID: 15026200.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir. AU - Hurt,Aeron C, AU - Barr,Ian G, AU - Hartel,Gunter, AU - Hampson,Alan W, PY - 2003/07/07/received PY - 2003/11/20/accepted PY - 2004/3/18/pubmed PY - 2004/7/21/medline PY - 2004/3/18/entrez SP - 37 EP - 45 JF - Antiviral research JO - Antiviral Res. VL - 62 IS - 1 N2 - Human influenza viruses isolated from Australasia (Australia and New Zealand) and South East Asia were analysed to determine their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir. A total of 532 strains isolated between 1998 and 2002 were tested using a fluorescence-based assay to measure the relative inhibition of NA activity over a range of drug concentrations. Based on median IC50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influenza B strains. Influenza A viruses with a N1 subtype and influenza B strains both demonstrated a greater sensitivity to zanamivir than to oseltamivir carboxylate, whereas influenza A strains with a N2 subtype were more susceptible to oseltamivir carboxylate. For each of the neuraminidase types, IC50 values for viruses from Australasia and South East Asia were found to be comparable. Based on the data prior to and following the licensing of the drugs into the respective regions, the use of the NA inhibitors did not appear to have a significant impact on the susceptibility of the viruses tested to zanamivir or oseltamivir carboxylate. SN - 0166-3542 UR - https://www.unboundmedicine.com/medline/citation/15026200/Susceptibility_of_human_influenza_viruses_from_Australasia_and_South_East_Asia_to_the_neuraminidase_inhibitors_zanamivir_and_oseltamivir_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166354203002961 DB - PRIME DP - Unbound Medicine ER -