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Diphenhydramine in the treatment of akathisia induced by prochlorperazine.
J Emerg Med. 2004 Apr; 26(3):265-70.JE

Abstract

Dopamine D(2) antagonists are known to induce akathisia, the emergency management of which remains undetermined. We sought to evaluate the effectiveness of diphenhydramine in the treatment of akathisia induced by 10 mg intravenous prochlorperazine. This prospective, open-label, uncontrolled study evaluated a cohort of akathisic adult Emergency Department patients who were participating in a series of three studies of acute akathisia at an academic medical center. Each subject received intravenous diphenhydramine, with akathisia measurements (graded from 0-17 points) performed just before and 30 min after infusion. Mean scores were calculated using descriptive statistical analyses. The effect of treatment was evaluated using the paired t-test. For the 87 akathisic patients, the mean score before treatment was 9.8 +/- 3.6, and after treatment was 1.2 +/- 2.6, a mean reduction of 8.5 +/- 3.8 (95% confidence interval [CI], 7.8 to 9.4; p < 0.0001). In conclusion, intravenous diphenhydramine rapidly reduces signs and symptoms of acute akathisia induced by prochlorperazine.

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Authors+Show Affiliations

Vinson DR
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington, USA.

MeSH

AdolescentAdultAkathisia, Drug-InducedAntiparkinson AgentsCohort StudiesDiphenhydramineDopamine AntagonistsDose-Response Relationship, DrugFemaleHumansInfusions, IntravenousMaleMiddle AgedProchlorperazineProspective StudiesTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15028322

Citation

Vinson, David R.. "Diphenhydramine in the Treatment of Akathisia Induced By Prochlorperazine." The Journal of Emergency Medicine, vol. 26, no. 3, 2004, pp. 265-70.
Vinson DR. Diphenhydramine in the treatment of akathisia induced by prochlorperazine. J Emerg Med. 2004;26(3):265-70.
Vinson, D. R. (2004). Diphenhydramine in the treatment of akathisia induced by prochlorperazine. The Journal of Emergency Medicine, 26(3), 265-70.
Vinson DR. Diphenhydramine in the Treatment of Akathisia Induced By Prochlorperazine. J Emerg Med. 2004;26(3):265-70. PubMed PMID: 15028322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenhydramine in the treatment of akathisia induced by prochlorperazine. A1 - Vinson,David R, PY - 2002/12/10/received PY - 2003/09/05/revised PY - 2003/11/03/accepted PY - 2004/3/19/pubmed PY - 2004/8/6/medline PY - 2004/3/19/entrez SP - 265 EP - 70 JF - The Journal of emergency medicine JO - J Emerg Med VL - 26 IS - 3 N2 - Dopamine D(2) antagonists are known to induce akathisia, the emergency management of which remains undetermined. We sought to evaluate the effectiveness of diphenhydramine in the treatment of akathisia induced by 10 mg intravenous prochlorperazine. This prospective, open-label, uncontrolled study evaluated a cohort of akathisic adult Emergency Department patients who were participating in a series of three studies of acute akathisia at an academic medical center. Each subject received intravenous diphenhydramine, with akathisia measurements (graded from 0-17 points) performed just before and 30 min after infusion. Mean scores were calculated using descriptive statistical analyses. The effect of treatment was evaluated using the paired t-test. For the 87 akathisic patients, the mean score before treatment was 9.8 +/- 3.6, and after treatment was 1.2 +/- 2.6, a mean reduction of 8.5 +/- 3.8 (95% confidence interval [CI], 7.8 to 9.4; p < 0.0001). In conclusion, intravenous diphenhydramine rapidly reduces signs and symptoms of acute akathisia induced by prochlorperazine. SN - 0736-4679 UR - https://www.unboundmedicine.com/medline/citation/15028322/Diphenhydramine_in_the_treatment_of_akathisia_induced_by_prochlorperazine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S073646790300372X DB - PRIME DP - Unbound Medicine ER -