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Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn.
J Neurosci. 2004 Mar 17; 24(11):2774-81.JN

Abstract

NMDA receptors have the potential to produce complex activity-dependent regulation of transmitter release when localized presynaptically. In the somatosensory system, NMDA receptors have been immunocytochemically detected on presynaptic terminals of primary afferents, and these have been proposed to drive release of substance P from central terminals of a subset of nociceptors in the spinal cord dorsal horn. Here we report that functional NMDA receptors are indeed present at or near the central terminals of primary afferent fibers. Furthermore, we show that activation of these presynaptic receptors results in an inhibition of glutamate release from the terminals. Some of these NMDA receptors may be expressed in the preterminal axon and regulate the extent to which action potentials invade the extensive central arborizations of primary sensory neurons.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy. bardoni@unimo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15028770

Citation

Bardoni, Rita, et al. "Presynaptic NMDA Receptors Modulate Glutamate Release From Primary Sensory Neurons in Rat Spinal Cord Dorsal Horn." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 24, no. 11, 2004, pp. 2774-81.
Bardoni R, Torsney C, Tong CK, et al. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci. 2004;24(11):2774-81.
Bardoni, R., Torsney, C., Tong, C. K., Prandini, M., & MacDermott, A. B. (2004). Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 24(11), 2774-81.
Bardoni R, et al. Presynaptic NMDA Receptors Modulate Glutamate Release From Primary Sensory Neurons in Rat Spinal Cord Dorsal Horn. J Neurosci. 2004 Mar 17;24(11):2774-81. PubMed PMID: 15028770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. AU - Bardoni,Rita, AU - Torsney,Carole, AU - Tong,Chi-Kun, AU - Prandini,Massimiliano, AU - MacDermott,Amy B, PY - 2004/3/19/pubmed PY - 2004/5/29/medline PY - 2004/3/19/entrez SP - 2774 EP - 81 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J. Neurosci. VL - 24 IS - 11 N2 - NMDA receptors have the potential to produce complex activity-dependent regulation of transmitter release when localized presynaptically. In the somatosensory system, NMDA receptors have been immunocytochemically detected on presynaptic terminals of primary afferents, and these have been proposed to drive release of substance P from central terminals of a subset of nociceptors in the spinal cord dorsal horn. Here we report that functional NMDA receptors are indeed present at or near the central terminals of primary afferent fibers. Furthermore, we show that activation of these presynaptic receptors results in an inhibition of glutamate release from the terminals. Some of these NMDA receptors may be expressed in the preterminal axon and regulate the extent to which action potentials invade the extensive central arborizations of primary sensory neurons. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/15028770/Presynaptic_NMDA_receptors_modulate_glutamate_release_from_primary_sensory_neurons_in_rat_spinal_cord_dorsal_horn_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=15028770 DB - PRIME DP - Unbound Medicine ER -