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Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24-h patch test and tape stripping.
Br J Dermatol. 2004 Mar; 150(3):493-9.BJ

Abstract

BACKGROUND

Little is known of the predictive value of methods to test an individual's susceptibility to acquiring occupational contact dermatitis. Recently, the recovery rate after induced irritation was suggested for this purpose. Although it is likely that repeated exposure to sodium lauryl sulphate (SLS) is preferable to a single application, there is little evidence to support this idea. Similarly, little is known about whether the outcome of a repeated SLS test can be predicted by a brief test.

OBJECTIVES

We studied the relationship between the skin reaction after a repeated SLS test and two brief tests, devoting special attention to the recovery rate.

METHODS

In 29 healthy volunteers, we measured transepidermal water loss (TEWL) and erythema after applying 0.03, 0.1 and 0.3% SLS for 6 h, 3 days per week, over a course of 3 weeks. The data were compared with the effects after applying 0.1, 0.3 and 1.0% SLS for 24 h and with 10 and 15 repetitions of tape stripping.

RESULTS

A poor correlation was found between the repeated test and the brief SLS test, or tape stripping, when using an increase in TEWL (r = 0.04 and 0.26, respectively) or its recovery rate (r = - 0.01 and 0.42, respectively).

CONCLUSIONS

We presume that in a repeated test of sufficient duration, additional mechanisms come into play that are absent in a brief test, e.g. an alteration in the thickness of the epidermis, with a resulting change in the permeability of SLS. When such an effect differs between subjects it could explain the lack of agreement between the acute and the repeated tests. At present, a brief irritation test will, in all likelihood, be unable to assess an individual's susceptibility to occupational contact dermatitis.

Authors+Show Affiliations

Koopman DG
Coronel Institute for Occupational and Environmental Health, Academic Medical Centre, University of Amsterdam, the Netherlands.
Kezić S
No affiliation info available
Verberk MM
No affiliation info available

MeSH

AdultDermatitis, Allergic ContactDermatitis, OccupationalErythemaFemaleHumansHypersensitivity, ImmediateMalePatch TestsPermeabilitySkinSodium Dodecyl SulfateWater Loss, Insensible

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15030332

Citation

Koopman, D G., et al. "Skin Reaction and Recovery: a Repeated Sodium Lauryl Sulphate Patch Test Vs. a 24-h Patch Test and Tape Stripping." The British Journal of Dermatology, vol. 150, no. 3, 2004, pp. 493-9.
Koopman DG, Kezić S, Verberk MM. Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24-h patch test and tape stripping. Br J Dermatol. 2004;150(3):493-9.
Koopman, D. G., Kezić, S., & Verberk, M. M. (2004). Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24-h patch test and tape stripping. The British Journal of Dermatology, 150(3), 493-9.
Koopman DG, Kezić S, Verberk MM. Skin Reaction and Recovery: a Repeated Sodium Lauryl Sulphate Patch Test Vs. a 24-h Patch Test and Tape Stripping. Br J Dermatol. 2004;150(3):493-9. PubMed PMID: 15030332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24-h patch test and tape stripping. AU - Koopman,D G, AU - Kezić,S, AU - Verberk,M M, PY - 2004/3/20/pubmed PY - 2004/5/5/medline PY - 2004/3/20/entrez SP - 493 EP - 9 JF - The British journal of dermatology JO - Br J Dermatol VL - 150 IS - 3 N2 - BACKGROUND: Little is known of the predictive value of methods to test an individual's susceptibility to acquiring occupational contact dermatitis. Recently, the recovery rate after induced irritation was suggested for this purpose. Although it is likely that repeated exposure to sodium lauryl sulphate (SLS) is preferable to a single application, there is little evidence to support this idea. Similarly, little is known about whether the outcome of a repeated SLS test can be predicted by a brief test. OBJECTIVES: We studied the relationship between the skin reaction after a repeated SLS test and two brief tests, devoting special attention to the recovery rate. METHODS: In 29 healthy volunteers, we measured transepidermal water loss (TEWL) and erythema after applying 0.03, 0.1 and 0.3% SLS for 6 h, 3 days per week, over a course of 3 weeks. The data were compared with the effects after applying 0.1, 0.3 and 1.0% SLS for 24 h and with 10 and 15 repetitions of tape stripping. RESULTS: A poor correlation was found between the repeated test and the brief SLS test, or tape stripping, when using an increase in TEWL (r = 0.04 and 0.26, respectively) or its recovery rate (r = - 0.01 and 0.42, respectively). CONCLUSIONS: We presume that in a repeated test of sufficient duration, additional mechanisms come into play that are absent in a brief test, e.g. an alteration in the thickness of the epidermis, with a resulting change in the permeability of SLS. When such an effect differs between subjects it could explain the lack of agreement between the acute and the repeated tests. At present, a brief irritation test will, in all likelihood, be unable to assess an individual's susceptibility to occupational contact dermatitis. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/15030332/Skin_reaction_and_recovery:_a_repeated_sodium_lauryl_sulphate_patch_test_vs__a_24_h_patch_test_and_tape_stripping_ DB - PRIME DP - Unbound Medicine ER -