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SARS-associated coronavirus transmission, United States.
Emerg Infect Dis. 2004 Feb; 10(2):225-31.EI

Abstract

To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.

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Authors+Show Affiliations

Isakbaeva ET
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. iae4@cdc.gov
Khetsuriani N
No affiliation info available
Beard RS
No affiliation info available
Peck A
No affiliation info available
Erdman D
No affiliation info available
Monroe SS
No affiliation info available
Tong S
No affiliation info available
Ksiazek TG
No affiliation info available
Lowther S
No affiliation info available
Pandya-Smith I
No affiliation info available
Anderson LJ
No affiliation info available
Lingappa J
No affiliation info available
Widdowson MA
No affiliation info available
SARS Investigation Group
No affiliation info available

MeSH

AdolescentAdultChildContact TracingDisease OutbreaksFamily CharacteristicsFecesFemaleHumansMaleMiddle AgedSevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory SyndromeSputumTime FactorsUnited States

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15030687

Citation

Isakbaeva, Elmira T., et al. "SARS-associated Coronavirus Transmission, United States." Emerging Infectious Diseases, vol. 10, no. 2, 2004, pp. 225-31.
Isakbaeva ET, Khetsuriani N, Beard RS, et al. SARS-associated coronavirus transmission, United States. Emerg Infect Dis. 2004;10(2):225-31.
Isakbaeva, E. T., Khetsuriani, N., Beard, R. S., Peck, A., Erdman, D., Monroe, S. S., Tong, S., Ksiazek, T. G., Lowther, S., Pandya-Smith, I., Anderson, L. J., Lingappa, J., & Widdowson, M. A. (2004). SARS-associated coronavirus transmission, United States. Emerging Infectious Diseases, 10(2), 225-31.
Isakbaeva ET, et al. SARS-associated Coronavirus Transmission, United States. Emerg Infect Dis. 2004;10(2):225-31. PubMed PMID: 15030687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-associated coronavirus transmission, United States. AU - Isakbaeva,Elmira T, AU - Khetsuriani,Nino, AU - Beard,R Suzanne, AU - Peck,Angela, AU - Erdman,Dean, AU - Monroe,Stephan S, AU - Tong,Suxiang, AU - Ksiazek,Thomas G, AU - Lowther,Sara, AU - Pandya-Smith,Indra, AU - Anderson,Larry J, AU - Lingappa,Jairam, AU - Widdowson,Marc-Alain, AU - ,, PY - 2004/3/20/pubmed PY - 2004/5/12/medline PY - 2004/3/20/entrez SP - 225 EP - 31 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 10 IS - 2 N2 - To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection. SN - 1080-6040 UR - https://www.unboundmedicine.com/medline/citation/15030687/SARS_associated_coronavirus_transmission_United_States_ DB - PRIME DP - Unbound Medicine ER -