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Tipping the balance toward longevity.
Dev Cell. 2004 Mar; 6(3):315-6.DC

Abstract

Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.

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Authors+Show Affiliations

Antebi A
Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.

MeSH

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DeathForkhead Transcription FactorsGene SilencingLongevitySirtuinsTranscription FactorsTumor Suppressor Protein p53

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15030753

Citation

Antebi, Adam. "Tipping the Balance Toward Longevity." Developmental Cell, vol. 6, no. 3, 2004, pp. 315-6.
Antebi A. Tipping the balance toward longevity. Dev Cell. 2004;6(3):315-6.
Antebi, A. (2004). Tipping the balance toward longevity. Developmental Cell, 6(3), 315-6.
Antebi A. Tipping the Balance Toward Longevity. Dev Cell. 2004;6(3):315-6. PubMed PMID: 15030753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tipping the balance toward longevity. A1 - Antebi,Adam, PY - 2004/3/20/pubmed PY - 2004/4/28/medline PY - 2004/3/20/entrez SP - 315 EP - 6 JF - Developmental cell JO - Dev Cell VL - 6 IS - 3 N2 - Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance. SN - 1534-5807 UR - https://www.unboundmedicine.com/medline/citation/15030753/Tipping_the_balance_toward_longevity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1534-5807(04)00068-1 DB - PRIME DP - Unbound Medicine ER -