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Tipping the balance toward longevity.
Dev Cell. 2004 Mar; 6(3):315-6.DC

Abstract

Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.

Authors+Show Affiliations

Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15030753

Citation

Antebi, Adam. "Tipping the Balance Toward Longevity." Developmental Cell, vol. 6, no. 3, 2004, pp. 315-6.
Antebi A. Tipping the balance toward longevity. Dev Cell. 2004;6(3):315-6.
Antebi, A. (2004). Tipping the balance toward longevity. Developmental Cell, 6(3), 315-6.
Antebi A. Tipping the Balance Toward Longevity. Dev Cell. 2004;6(3):315-6. PubMed PMID: 15030753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tipping the balance toward longevity. A1 - Antebi,Adam, PY - 2004/3/20/pubmed PY - 2004/4/28/medline PY - 2004/3/20/entrez SP - 315 EP - 6 JF - Developmental cell JO - Dev. Cell VL - 6 IS - 3 N2 - Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance. SN - 1534-5807 UR - https://www.unboundmedicine.com/medline/citation/15030753/Tipping_the_balance_toward_longevity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1534-5807(04)00068-1 DB - PRIME DP - Unbound Medicine ER -