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Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke.
Stroke. 2004 May; 35(5):1090-4.S

Abstract

BACKGROUND AND PURPOSE

Occlusive thrombosis is an important component of small- and large-vessel ischemic stroke. Endogenous tissue plasminogen activator (TPA) is the primary mediator of intravascular fibrinolysis and is predominantly expressed by the endothelium of small vessels. The acute release of TPA is influenced by the TPA -7351C/T polymorphism and therefore may play an important role in the pathogenesis of lacunar stroke. In this study, we investigated the risk of lacunar and nonlacunar ischemic stroke associated with the TPA -7351C/T polymorphism.

METHODS

We conducted a case-control study of 182 cases of ischemic stroke and 301 community controls. Participants were evaluated for known cerebrovascular risk factors, and the TPA -7351C/T genotype was established by a polymerase chain reaction (PCR) method. Logistic regression was used to determine the risk of lacunar and nonlacunar ischemic stroke associated with the TPA -7351C/T polymorphism.

RESULTS

The prevalence of the TPA -7351 CC, CT, and TT genotypes were 46%, 45%, and 9% for controls and 41%, 46%, and 13% for stroke patients, respectively. After adjustment for known cerebrovascular risk factors, the TT genotype was significantly associated with ischemic stroke (OR: 1.9; 95% CI: 1.01 to 3.6). Stratification for stroke subtype showed a significant association between the TT genotype and lacunar stroke but not nonlacunar stroke (OR: 2.7; 95% CI: 1.1 to 6.7).

CONCLUSIONS

The TPA -7351C/T polymorphism is an independent risk factor for lacunar stroke. The findings suggest that impaired fibrinolysis may play a role in the pathogenesis of lacunar stroke.

Authors+Show Affiliations

Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville South, South Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15031453

Citation

Jannes, Jim, et al. "Tissue Plasminogen Activator -7351C/T Enhancer Polymorphism Is a Risk Factor for Lacunar Stroke." Stroke, vol. 35, no. 5, 2004, pp. 1090-4.
Jannes J, Hamilton-Bruce MA, Pilotto L, et al. Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke. Stroke. 2004;35(5):1090-4.
Jannes, J., Hamilton-Bruce, M. A., Pilotto, L., Smith, B. J., Mullighan, C. G., Bardy, P. G., & Koblar, S. A. (2004). Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke. Stroke, 35(5), 1090-4.
Jannes J, et al. Tissue Plasminogen Activator -7351C/T Enhancer Polymorphism Is a Risk Factor for Lacunar Stroke. Stroke. 2004;35(5):1090-4. PubMed PMID: 15031453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke. AU - Jannes,Jim, AU - Hamilton-Bruce,Monica A, AU - Pilotto,Louis, AU - Smith,Brian J, AU - Mullighan,Charles G, AU - Bardy,Peter G, AU - Koblar,Simon A, Y1 - 2004/03/18/ PY - 2004/3/20/pubmed PY - 2004/5/20/medline PY - 2004/3/20/entrez SP - 1090 EP - 4 JF - Stroke JO - Stroke VL - 35 IS - 5 N2 - BACKGROUND AND PURPOSE: Occlusive thrombosis is an important component of small- and large-vessel ischemic stroke. Endogenous tissue plasminogen activator (TPA) is the primary mediator of intravascular fibrinolysis and is predominantly expressed by the endothelium of small vessels. The acute release of TPA is influenced by the TPA -7351C/T polymorphism and therefore may play an important role in the pathogenesis of lacunar stroke. In this study, we investigated the risk of lacunar and nonlacunar ischemic stroke associated with the TPA -7351C/T polymorphism. METHODS: We conducted a case-control study of 182 cases of ischemic stroke and 301 community controls. Participants were evaluated for known cerebrovascular risk factors, and the TPA -7351C/T genotype was established by a polymerase chain reaction (PCR) method. Logistic regression was used to determine the risk of lacunar and nonlacunar ischemic stroke associated with the TPA -7351C/T polymorphism. RESULTS: The prevalence of the TPA -7351 CC, CT, and TT genotypes were 46%, 45%, and 9% for controls and 41%, 46%, and 13% for stroke patients, respectively. After adjustment for known cerebrovascular risk factors, the TT genotype was significantly associated with ischemic stroke (OR: 1.9; 95% CI: 1.01 to 3.6). Stratification for stroke subtype showed a significant association between the TT genotype and lacunar stroke but not nonlacunar stroke (OR: 2.7; 95% CI: 1.1 to 6.7). CONCLUSIONS: The TPA -7351C/T polymorphism is an independent risk factor for lacunar stroke. The findings suggest that impaired fibrinolysis may play a role in the pathogenesis of lacunar stroke. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/15031453/Tissue_plasminogen_activator__7351C/T_enhancer_polymorphism_is_a_risk_factor_for_lacunar_stroke_ L2 - https://www.ahajournals.org/doi/10.1161/01.STR.0000124123.76658.6c?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -