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Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels.
Int Arch Allergy Immunol. 2004 Apr; 133(4):365-70.IA

Abstract

BACKGROUND

Exposure and sensitization to indoor allergens have been associated with the development of asthma and other allergic diseases in many parts of the world. It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area.

METHODS

Concentrations of major allergens of mites, cockroach, cat and dog were measured in dust samples from homes of 24 mite-allergic patients living in Ribeirão Preto, Brazil. Allergen concentrations were quantitated by monoclonal antibody-based ELISA. Mite-impermeable mattress and pillow covers were applied to beds in the homes of 19 of the 24 patients, and group 1 mite allergen levels were measured 1 and 6 months following intervention.

RESULTS

Patients were exposed to high concentrations of mite allergens in their homes. 87.5% of the homes presented concentrations of group 1 allergens >10 microg/g of dust in at least one site. Cockroach allergen concentrations were low in most samples. Dog allergen concentrations were significantly higher in homes with dogs as compared to those without dogs. Mean concentrations of cat allergen were 0.1 microg/g. Mite allergen concentrations in bedding samples dropped from 24 microg/g at baseline to 0.9 and 1.0 microg/g, respectively, 1 and 6 months following encasement of mattresses and pillows.

CONCLUSIONS

Significant mite allergen reduction can be achieved in an area of high degree of exposure to mite allergens. Further studies evaluating the effect of this reduction on symptoms and airway inflammation will be necessary to establish the effectiveness of mite avoidance measures in our area.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15031610

Citation

Tobias, Kátia R C., et al. "Exposure to Indoor Allergens in Homes of Patients With Asthma And/or Rhinitis in Southeast Brazil: Effect of Mattress and Pillow Covers On Mite Allergen Levels." International Archives of Allergy and Immunology, vol. 133, no. 4, 2004, pp. 365-70.
Tobias KR, Ferriani VP, Chapman MD, et al. Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels. Int Arch Allergy Immunol. 2004;133(4):365-70.
Tobias, K. R., Ferriani, V. P., Chapman, M. D., & Arruda, L. K. (2004). Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels. International Archives of Allergy and Immunology, 133(4), 365-70.
Tobias KR, et al. Exposure to Indoor Allergens in Homes of Patients With Asthma And/or Rhinitis in Southeast Brazil: Effect of Mattress and Pillow Covers On Mite Allergen Levels. Int Arch Allergy Immunol. 2004;133(4):365-70. PubMed PMID: 15031610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels. AU - Tobias,Kátia R C, AU - Ferriani,Virginia P L, AU - Chapman,Martin D, AU - Arruda,L Karla, Y1 - 2004/03/17/ PY - 2003/04/03/received PY - 2003/11/07/accepted PY - 2004/3/20/pubmed PY - 2004/5/11/medline PY - 2004/3/20/entrez SP - 365 EP - 70 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 133 IS - 4 N2 - BACKGROUND: Exposure and sensitization to indoor allergens have been associated with the development of asthma and other allergic diseases in many parts of the world. It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area. METHODS: Concentrations of major allergens of mites, cockroach, cat and dog were measured in dust samples from homes of 24 mite-allergic patients living in Ribeirão Preto, Brazil. Allergen concentrations were quantitated by monoclonal antibody-based ELISA. Mite-impermeable mattress and pillow covers were applied to beds in the homes of 19 of the 24 patients, and group 1 mite allergen levels were measured 1 and 6 months following intervention. RESULTS: Patients were exposed to high concentrations of mite allergens in their homes. 87.5% of the homes presented concentrations of group 1 allergens >10 microg/g of dust in at least one site. Cockroach allergen concentrations were low in most samples. Dog allergen concentrations were significantly higher in homes with dogs as compared to those without dogs. Mean concentrations of cat allergen were 0.1 microg/g. Mite allergen concentrations in bedding samples dropped from 24 microg/g at baseline to 0.9 and 1.0 microg/g, respectively, 1 and 6 months following encasement of mattresses and pillows. CONCLUSIONS: Significant mite allergen reduction can be achieved in an area of high degree of exposure to mite allergens. Further studies evaluating the effect of this reduction on symptoms and airway inflammation will be necessary to establish the effectiveness of mite avoidance measures in our area. SN - 1018-2438 UR - https://www.unboundmedicine.com/medline/citation/15031610/Exposure_to_indoor_allergens_in_homes_of_patients_with_asthma_and/or_rhinitis_in_southeast_Brazil:_effect_of_mattress_and_pillow_covers_on_mite_allergen_levels_ L2 - https://www.karger.com?DOI=10.1159/000077356 DB - PRIME DP - Unbound Medicine ER -