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Neurodegenerative diseases and oxidative stress.
Nat Rev Drug Discov. 2004 Mar; 3(3):205-14.NR

Abstract

Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.

Authors+Show Affiliations

Department of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Victoria 3010, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15031734

Citation

Barnham, Kevin J., et al. "Neurodegenerative Diseases and Oxidative Stress." Nature Reviews. Drug Discovery, vol. 3, no. 3, 2004, pp. 205-14.
Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov. 2004;3(3):205-14.
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004). Neurodegenerative diseases and oxidative stress. Nature Reviews. Drug Discovery, 3(3), 205-14.
Barnham KJ, Masters CL, Bush AI. Neurodegenerative Diseases and Oxidative Stress. Nat Rev Drug Discov. 2004;3(3):205-14. PubMed PMID: 15031734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurodegenerative diseases and oxidative stress. AU - Barnham,Kevin J, AU - Masters,Colin L, AU - Bush,Ashley I, PY - 2004/3/20/pubmed PY - 2004/4/9/medline PY - 2004/3/20/entrez SP - 205 EP - 14 JF - Nature reviews. Drug discovery JO - Nat Rev Drug Discov VL - 3 IS - 3 N2 - Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies. SN - 1474-1776 UR - https://www.unboundmedicine.com/medline/citation/15031734/Neurodegenerative_diseases_and_oxidative_stress_ L2 - http://dx.doi.org/10.1038/nrd1330 DB - PRIME DP - Unbound Medicine ER -