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Regulation of inflammatory responses by oxidized phospholipids: structure-function relationships.
Curr Pharm Des. 2004; 10(8):915-21.CP

Abstract

Increasing evidence points to the role of oxidized phospholipids as modulators of inflammatory processes. These modified phospholipids are derived from lipoproteins or cellular membranes and accumulate at sites of inflammation such as atherosclerotic lesions. It has been shown that oxidized phospholipids influence a variety of cellular functions such as chemokine production and expression of adhesion molecules. Furthermore, recent reports indicate that oxidized phospholipids act as ligands for pattern-recognition receptors which detect conserved pathogen-associated molecular patterns during innate immune defense. Thus, the diversity of individual phospholipid oxidation products reflects the many aspects of the inflammatory process they influence. In this review, we focus on structural features used to classify different oxidized phospholipids and how they relate to specific biological responses. As the chemical identification of oxidized phospholipid products proceeds, distinctive structural motifs emerge that can help us to understand the mechanism of action of these unique compounds and how to intervene for therapeutic purposes.

Authors+Show Affiliations

Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15032694

Citation

Furnkranz, A, and N Leitinger. "Regulation of Inflammatory Responses By Oxidized Phospholipids: Structure-function Relationships." Current Pharmaceutical Design, vol. 10, no. 8, 2004, pp. 915-21.
Furnkranz A, Leitinger N. Regulation of inflammatory responses by oxidized phospholipids: structure-function relationships. Curr Pharm Des. 2004;10(8):915-21.
Furnkranz, A., & Leitinger, N. (2004). Regulation of inflammatory responses by oxidized phospholipids: structure-function relationships. Current Pharmaceutical Design, 10(8), 915-21.
Furnkranz A, Leitinger N. Regulation of Inflammatory Responses By Oxidized Phospholipids: Structure-function Relationships. Curr Pharm Des. 2004;10(8):915-21. PubMed PMID: 15032694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of inflammatory responses by oxidized phospholipids: structure-function relationships. AU - Furnkranz,A, AU - Leitinger,N, PY - 2004/3/23/pubmed PY - 2004/12/16/medline PY - 2004/3/23/entrez SP - 915 EP - 21 JF - Current pharmaceutical design JO - Curr Pharm Des VL - 10 IS - 8 N2 - Increasing evidence points to the role of oxidized phospholipids as modulators of inflammatory processes. These modified phospholipids are derived from lipoproteins or cellular membranes and accumulate at sites of inflammation such as atherosclerotic lesions. It has been shown that oxidized phospholipids influence a variety of cellular functions such as chemokine production and expression of adhesion molecules. Furthermore, recent reports indicate that oxidized phospholipids act as ligands for pattern-recognition receptors which detect conserved pathogen-associated molecular patterns during innate immune defense. Thus, the diversity of individual phospholipid oxidation products reflects the many aspects of the inflammatory process they influence. In this review, we focus on structural features used to classify different oxidized phospholipids and how they relate to specific biological responses. As the chemical identification of oxidized phospholipid products proceeds, distinctive structural motifs emerge that can help us to understand the mechanism of action of these unique compounds and how to intervene for therapeutic purposes. SN - 1381-6128 UR - https://www.unboundmedicine.com/medline/citation/15032694/Regulation_of_inflammatory_responses_by_oxidized_phospholipids:_structure_function_relationships_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1381-6128&volume=10&issue=8&spage=915&aulast=Furnkranz DB - PRIME DP - Unbound Medicine ER -