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Dopamine agonists and sleepiness in PD: review of the literature and personal findings.
Sleep Med. 2004 Mar; 5(2):189-93.SM

Abstract

BACKGROUND AND PURPOSE

This study is aimed at evaluating daytime sleepiness in a series of Parkinson's disease (PD) patients chronically treated with dopamine agonists (DAs) alone or in combination with L-Dopa.

PATIENTS AND METHODS

A preliminary series of 22 non-demented, adult PD patients (mean age 68.9, 13 men and 9 women) were evaluated by means of structured sleep interview, Epworth sleepiness scale (ESS) and 24-h ambulatory polysomnography (A-PSG).

RESULTS

Sleep attacks (SAs) were reported by 32% of the patients, in three of them (43%) after DA treatment was initiated (alone or in addition to L-Dopa). In two patients, both with chronic use of ropinirole, we documented NREM SAs during a continuous ambulatory polysomnography (A-PSG) performed in the patients' real-life settings. The subjects experiencing SAs showed a higher degree of daytime sleep propensity than those without SA, having higher ESS scores and a higher proportion of microsleeps and intentional naps on A-PSG. Interestingly, we found that nocturnal total sleep time is higher in PD patients with SAs than in the others.

CONCLUSIONS

All in all, our data indicate that SAs are an extreme manifestation of increased daytime sleepiness. The occurrence of SAs in our series of PD patients is unlikely to depend simply on the demands of homeostatic mechanisms.

Authors+Show Affiliations

Unit of Sleep Medicine and Epilepsy, IRCCS C. Mondino Institute of Neurology, Pavia, Italy. raffaele.manni@mondino.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15033142

Citation

Manni, Raffaele, et al. "Dopamine Agonists and Sleepiness in PD: Review of the Literature and Personal Findings." Sleep Medicine, vol. 5, no. 2, 2004, pp. 189-93.
Manni R, Terzaghi M, Sartori I, et al. Dopamine agonists and sleepiness in PD: review of the literature and personal findings. Sleep Med. 2004;5(2):189-93.
Manni, R., Terzaghi, M., Sartori, I., Mancini, F., & Pacchetti, C. (2004). Dopamine agonists and sleepiness in PD: review of the literature and personal findings. Sleep Medicine, 5(2), 189-93.
Manni R, et al. Dopamine Agonists and Sleepiness in PD: Review of the Literature and Personal Findings. Sleep Med. 2004;5(2):189-93. PubMed PMID: 15033142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine agonists and sleepiness in PD: review of the literature and personal findings. AU - Manni,Raffaele, AU - Terzaghi,Michele, AU - Sartori,Ivana, AU - Mancini,Francesca, AU - Pacchetti,Claudio, PY - 2002/12/01/received PY - 2003/01/01/revised PY - 2003/01/15/accepted PY - 2004/3/23/pubmed PY - 2004/7/3/medline PY - 2004/3/23/entrez SP - 189 EP - 93 JF - Sleep medicine JO - Sleep Med VL - 5 IS - 2 N2 - BACKGROUND AND PURPOSE: This study is aimed at evaluating daytime sleepiness in a series of Parkinson's disease (PD) patients chronically treated with dopamine agonists (DAs) alone or in combination with L-Dopa. PATIENTS AND METHODS: A preliminary series of 22 non-demented, adult PD patients (mean age 68.9, 13 men and 9 women) were evaluated by means of structured sleep interview, Epworth sleepiness scale (ESS) and 24-h ambulatory polysomnography (A-PSG). RESULTS: Sleep attacks (SAs) were reported by 32% of the patients, in three of them (43%) after DA treatment was initiated (alone or in addition to L-Dopa). In two patients, both with chronic use of ropinirole, we documented NREM SAs during a continuous ambulatory polysomnography (A-PSG) performed in the patients' real-life settings. The subjects experiencing SAs showed a higher degree of daytime sleep propensity than those without SA, having higher ESS scores and a higher proportion of microsleeps and intentional naps on A-PSG. Interestingly, we found that nocturnal total sleep time is higher in PD patients with SAs than in the others. CONCLUSIONS: All in all, our data indicate that SAs are an extreme manifestation of increased daytime sleepiness. The occurrence of SAs in our series of PD patients is unlikely to depend simply on the demands of homeostatic mechanisms. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/15033142/Dopamine_agonists_and_sleepiness_in_PD:_review_of_the_literature_and_personal_findings_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389945704000085 DB - PRIME DP - Unbound Medicine ER -