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Effective regurgitant orifice area of rheumatic mitral insufficiency: response to angiotensin converting enzyme inhibitor treatment.
Anadolu Kardiyol Derg. 2004 Mar; 4(1):3-7.AK

Abstract

OBJECTIVE

This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements.

METHODS

Patients with rheumatic mitral insufficiency were divided into two groups: Study group (SG)-10 females, 2 males, aged 10-18 years, body surface area 1.49+/-0.05 m2, receiving digoxin therapy for at least one year and Control group (CG)-8 females, 4 males, aged 8-17 years, body surface area 1.38+/-0.07 m2, with no treatment. Patients in the two groups had no symptoms of cardiac failure. Angiotensin converting enzyme inhibitor therapy was given to SG patients on admission. Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin.

RESULTS

Study group's left ventricular end-diastolic volume (108.03+/-41.21 ml/m2), mitral stroke volume (510.37+/-321.58 ml/m2) and regurgitant volume (423.48+/-305.00 ml/m2) were significantly higher (p<0.05) on admission than in the CG (81.98+/-21.53 ml/m2, 315.34+/-207.38 ml/m2 and 245.77+/-179.84 ml/m2, respectively). Aortic stroke volume at the 20th day of therapy was significantly higher in SG than in the CG. Therapy with ACEI decreased significantly SG's left ventricular end-diastolic volume.

CONCLUSION

Angiotensin converting enzyme inhibitors should be started at an early stage of mitral regurgitation. The effective regurgitant orifice area is a feasible and easy method for the outpatient follow-up of mitral regurgitation.

Authors+Show Affiliations

Department of Pediatric Cardiology, Gazi University Medical Faculty, Ankara, Turkey. fst@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15033608

Citation

Tunaoğlu, F Sedef, et al. "Effective Regurgitant Orifice Area of Rheumatic Mitral Insufficiency: Response to Angiotensin Converting Enzyme Inhibitor Treatment." Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, vol. 4, no. 1, 2004, pp. 3-7.
Tunaoğlu FS, Olguntürk R, Kula S, et al. Effective regurgitant orifice area of rheumatic mitral insufficiency: response to angiotensin converting enzyme inhibitor treatment. Anadolu Kardiyol Derg. 2004;4(1):3-7.
Tunaoğlu, F. S., Olguntürk, R., Kula, S., & Oğuz, D. (2004). Effective regurgitant orifice area of rheumatic mitral insufficiency: response to angiotensin converting enzyme inhibitor treatment. Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, 4(1), 3-7.
Tunaoğlu FS, et al. Effective Regurgitant Orifice Area of Rheumatic Mitral Insufficiency: Response to Angiotensin Converting Enzyme Inhibitor Treatment. Anadolu Kardiyol Derg. 2004;4(1):3-7. PubMed PMID: 15033608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effective regurgitant orifice area of rheumatic mitral insufficiency: response to angiotensin converting enzyme inhibitor treatment. AU - Tunaoğlu,F Sedef, AU - Olguntürk,Rana, AU - Kula,Serdar, AU - Oğuz,Deniz, PY - 2004/3/23/pubmed PY - 2004/5/21/medline PY - 2004/3/23/entrez SP - 3 EP - 7 JF - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology JO - Anadolu Kardiyol Derg VL - 4 IS - 1 N2 - OBJECTIVE: This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements. METHODS: Patients with rheumatic mitral insufficiency were divided into two groups: Study group (SG)-10 females, 2 males, aged 10-18 years, body surface area 1.49+/-0.05 m2, receiving digoxin therapy for at least one year and Control group (CG)-8 females, 4 males, aged 8-17 years, body surface area 1.38+/-0.07 m2, with no treatment. Patients in the two groups had no symptoms of cardiac failure. Angiotensin converting enzyme inhibitor therapy was given to SG patients on admission. Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin. RESULTS: Study group's left ventricular end-diastolic volume (108.03+/-41.21 ml/m2), mitral stroke volume (510.37+/-321.58 ml/m2) and regurgitant volume (423.48+/-305.00 ml/m2) were significantly higher (p<0.05) on admission than in the CG (81.98+/-21.53 ml/m2, 315.34+/-207.38 ml/m2 and 245.77+/-179.84 ml/m2, respectively). Aortic stroke volume at the 20th day of therapy was significantly higher in SG than in the CG. Therapy with ACEI decreased significantly SG's left ventricular end-diastolic volume. CONCLUSION: Angiotensin converting enzyme inhibitors should be started at an early stage of mitral regurgitation. The effective regurgitant orifice area is a feasible and easy method for the outpatient follow-up of mitral regurgitation. SN - 1302-8723 UR - https://www.unboundmedicine.com/medline/citation/15033608/Effective_regurgitant_orifice_area_of_rheumatic_mitral_insufficiency:_response_to_angiotensin_converting_enzyme_inhibitor_treatment_ L2 - http://www.anatoljcardiol.com/linkout/?PMID=15033608 DB - PRIME DP - Unbound Medicine ER -