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Breast cancer in young women: clinical, histological and morphometric prognostic factors.
Anticancer Res. 1992 Jul-Aug; 12(4):1237-42.AR

Abstract

Clinical features, 8 histological features, 7 nuclear morphometric variables and 2 mitotic indices were entered in a univariate and in a multivariate survival analysis to assess their independent predictive value in 56 breast cancer patients under the age of 40 years who were followed up for over 10 years. The most important predictor of recurrence-free survival (RFS) in univariate analysis was the SD of nuclear perimetry (p = 0.003) followed by SD of nuclear area (p = 0.006), M/V index (p = 0.036), pN status (p = 0.046), nuclear area of 10 largest nuclei (p = 0.07), nuclear perimetry (p = 0.09) and nuclear area (p = 0.09) in that order. In pN(-) patients, SDPE (p = 0.04), SDNA (p = 0.07) and NA10 (p = 0.07) predicted RFS. In pN+ patients the most important predictor of RFS was the SDNA (p = 0.001) followed by NA 10 (p = 0.003), SDPE (p = 0.009), PE (p = 0.01), NA (p = 0.01) and Dmin (shortest diameter) (p = 0.04). In multivariate analysis the pN-status independently predicted RFS. Tumour size (p = 0.001), pN status (p = 0.002) and M/V-index (p = 0.079) were related to BS (breast cancer survival). In pN-patients, NA 10 (p = 0.097) predicted BS, whereas in pN+ tumours tumour size (p = 0.06) was the most important predictor of BS. In a multivariate analysis, tumour size (p = 0.02) and pN-status (p = 0.016) were independent predictors of BS.

Authors+Show Affiliations

Department of Surgery, University of Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1503415

Citation

Eskelinen, M, et al. "Breast Cancer in Young Women: Clinical, Histological and Morphometric Prognostic Factors." Anticancer Research, vol. 12, no. 4, 1992, pp. 1237-42.
Eskelinen M, Lipponen P, Aaltomaa S, et al. Breast cancer in young women: clinical, histological and morphometric prognostic factors. Anticancer Res. 1992;12(4):1237-42.
Eskelinen, M., Lipponen, P., Aaltomaa, S., Kosma, V. M., Syrjänen, K., & Alhava, E. (1992). Breast cancer in young women: clinical, histological and morphometric prognostic factors. Anticancer Research, 12(4), 1237-42.
Eskelinen M, et al. Breast Cancer in Young Women: Clinical, Histological and Morphometric Prognostic Factors. Anticancer Res. 1992 Jul-Aug;12(4):1237-42. PubMed PMID: 1503415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer in young women: clinical, histological and morphometric prognostic factors. AU - Eskelinen,M, AU - Lipponen,P, AU - Aaltomaa,S, AU - Kosma,V M, AU - Syrjänen,K, AU - Alhava,E, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 1237 EP - 42 JF - Anticancer research JO - Anticancer Res VL - 12 IS - 4 N2 - Clinical features, 8 histological features, 7 nuclear morphometric variables and 2 mitotic indices were entered in a univariate and in a multivariate survival analysis to assess their independent predictive value in 56 breast cancer patients under the age of 40 years who were followed up for over 10 years. The most important predictor of recurrence-free survival (RFS) in univariate analysis was the SD of nuclear perimetry (p = 0.003) followed by SD of nuclear area (p = 0.006), M/V index (p = 0.036), pN status (p = 0.046), nuclear area of 10 largest nuclei (p = 0.07), nuclear perimetry (p = 0.09) and nuclear area (p = 0.09) in that order. In pN(-) patients, SDPE (p = 0.04), SDNA (p = 0.07) and NA10 (p = 0.07) predicted RFS. In pN+ patients the most important predictor of RFS was the SDNA (p = 0.001) followed by NA 10 (p = 0.003), SDPE (p = 0.009), PE (p = 0.01), NA (p = 0.01) and Dmin (shortest diameter) (p = 0.04). In multivariate analysis the pN-status independently predicted RFS. Tumour size (p = 0.001), pN status (p = 0.002) and M/V-index (p = 0.079) were related to BS (breast cancer survival). In pN-patients, NA 10 (p = 0.097) predicted BS, whereas in pN+ tumours tumour size (p = 0.06) was the most important predictor of BS. In a multivariate analysis, tumour size (p = 0.02) and pN-status (p = 0.016) were independent predictors of BS. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/1503415/Breast_cancer_in_young_women:_clinical_histological_and_morphometric_prognostic_factors_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -