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Medications that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update.
Paediatr Drugs. 2004; 6(2):123-6.PD

Abstract

OBJECTIVE

To provide an updated list of the highly toxic medications in North America that can kill a 10 kg toddler upon ingestion of 1-2 dose units.

METHODS

All drugs available in North America were reviewed and their reported lethal doses in children or adults (where no pediatric data existed) were identified. The dose units of drugs available in North America were subsequently identified, followed by those dose units that could kill a toddler upon ingestion of 1-2 dose units or teaspoonfuls.

RESULTS

Tricyclic antidepressants, antipsychotics, quinine derivatives, calcium channel blockers, opioids, and oral hypoglycemics can kill a toddler with 1-2 dose units. This list of drugs was responsible for 40% of toddler fatalities reported to the American Association of Poison Control Center Toxic Exposure Surveillance System between 1990-2000.

CONCLUSION

Drugs that can kill a toddler with 1-2 dose units should be known to clinicians as such exposures warrant immediate and intensive management. A new system of special labeling of these drugs should be considered.

Authors+Show Affiliations

Bar-Oz B
The Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada.
Levichek Z
No affiliation info available
Koren G
No affiliation info available

MeSH

Administration, OralAnalgesics, OpioidAnnual Reports as TopicAnti-Arrhythmia AgentsAntidepressive Agents, TricyclicAntimalarialsAntipsychotic AgentsCalcium Channel BlockersCause of DeathChild, PreschoolDose-Response Relationship, DrugDrug-Related Side Effects and Adverse ReactionsHumansIron CompoundsPharmaceutical PreparationsPoison Control CentersPoisoningRetrospective StudiesTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15035652

Citation

Bar-Oz, Benjamin, et al. "Medications That Can Be Fatal for a Toddler With One Tablet or Teaspoonful: a 2004 Update." Paediatric Drugs, vol. 6, no. 2, 2004, pp. 123-6.
Bar-Oz B, Levichek Z, Koren G. Medications that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update. Paediatr Drugs. 2004;6(2):123-6.
Bar-Oz, B., Levichek, Z., & Koren, G. (2004). Medications that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update. Paediatric Drugs, 6(2), 123-6.
Bar-Oz B, Levichek Z, Koren G. Medications That Can Be Fatal for a Toddler With One Tablet or Teaspoonful: a 2004 Update. Paediatr Drugs. 2004;6(2):123-6. PubMed PMID: 15035652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medications that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update. AU - Bar-Oz,Benjamin, AU - Levichek,Zina, AU - Koren,Gideon, PY - 2004/3/24/pubmed PY - 2004/7/30/medline PY - 2004/3/24/entrez SP - 123 EP - 6 JF - Paediatric drugs JO - Paediatr Drugs VL - 6 IS - 2 N2 - OBJECTIVE: To provide an updated list of the highly toxic medications in North America that can kill a 10 kg toddler upon ingestion of 1-2 dose units. METHODS: All drugs available in North America were reviewed and their reported lethal doses in children or adults (where no pediatric data existed) were identified. The dose units of drugs available in North America were subsequently identified, followed by those dose units that could kill a toddler upon ingestion of 1-2 dose units or teaspoonfuls. RESULTS: Tricyclic antidepressants, antipsychotics, quinine derivatives, calcium channel blockers, opioids, and oral hypoglycemics can kill a toddler with 1-2 dose units. This list of drugs was responsible for 40% of toddler fatalities reported to the American Association of Poison Control Center Toxic Exposure Surveillance System between 1990-2000. CONCLUSION: Drugs that can kill a toddler with 1-2 dose units should be known to clinicians as such exposures warrant immediate and intensive management. A new system of special labeling of these drugs should be considered. SN - 1174-5878 UR - https://www.unboundmedicine.com/medline/citation/15035652/Medications_that_can_be_fatal_for_a_toddler_with_one_tablet_or_teaspoonful:_a_2004_update_ DB - PRIME DP - Unbound Medicine ER -