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Attenuation of potassium bromate-induced nephrotoxicity by coumarin (1,2-benzopyrone) in Wistar rats: chemoprevention against free radical-mediated renal oxidative stress and tumor promotion response.
Redox Rep. 2004; 9(1):19-28.RR

Abstract

We report the modulatory effect of coumarin (1,2-benzopyrone) on potassium bromate (KBrO(3)) mediated nephrotoxicity in Wistar rats. KBrO(3) (125 mg/kg body weight, i.p.) enhances gamma-glutamyl transpeptidase, renal lipid peroxidation, xanthine oxidase and hydrogen peroxide (H(2)O(2)) generation with reduction in renal glutathione content and antioxidant enzymes. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and [(3)H]-thymidine incorporation into renal DNA. Treatment of rats orally with coumarin (10 mg/kg body weight and 20 mg/kg body weight) resulted in a significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H(2)O(2) generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content (P < 0.01) and antioxidant enzymes were also recovered to significant level (P < 0.001). These results show that coumarin may be used as an effective chemopreventive agent against KBrO(3)-mediated renal oxidative stress, toxicity and tumor promotion response in Wistar rats.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15035824

Citation

Khan, Naghma, et al. "Attenuation of Potassium Bromate-induced Nephrotoxicity By Coumarin (1,2-benzopyrone) in Wistar Rats: Chemoprevention Against Free Radical-mediated Renal Oxidative Stress and Tumor Promotion Response." Redox Report : Communications in Free Radical Research, vol. 9, no. 1, 2004, pp. 19-28.
Khan N, Sharma S, Sultana S. Attenuation of potassium bromate-induced nephrotoxicity by coumarin (1,2-benzopyrone) in Wistar rats: chemoprevention against free radical-mediated renal oxidative stress and tumor promotion response. Redox Rep. 2004;9(1):19-28.
Khan, N., Sharma, S., & Sultana, S. (2004). Attenuation of potassium bromate-induced nephrotoxicity by coumarin (1,2-benzopyrone) in Wistar rats: chemoprevention against free radical-mediated renal oxidative stress and tumor promotion response. Redox Report : Communications in Free Radical Research, 9(1), 19-28.
Khan N, Sharma S, Sultana S. Attenuation of Potassium Bromate-induced Nephrotoxicity By Coumarin (1,2-benzopyrone) in Wistar Rats: Chemoprevention Against Free Radical-mediated Renal Oxidative Stress and Tumor Promotion Response. Redox Rep. 2004;9(1):19-28. PubMed PMID: 15035824.
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TY - JOUR T1 - Attenuation of potassium bromate-induced nephrotoxicity by coumarin (1,2-benzopyrone) in Wistar rats: chemoprevention against free radical-mediated renal oxidative stress and tumor promotion response. AU - Khan,Naghma, AU - Sharma,Sonia, AU - Sultana,Sarwat, PY - 2004/3/24/pubmed PY - 2004/12/24/medline PY - 2004/3/24/entrez SP - 19 EP - 28 JF - Redox report : communications in free radical research JO - Redox Rep VL - 9 IS - 1 N2 - We report the modulatory effect of coumarin (1,2-benzopyrone) on potassium bromate (KBrO(3)) mediated nephrotoxicity in Wistar rats. KBrO(3) (125 mg/kg body weight, i.p.) enhances gamma-glutamyl transpeptidase, renal lipid peroxidation, xanthine oxidase and hydrogen peroxide (H(2)O(2)) generation with reduction in renal glutathione content and antioxidant enzymes. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and [(3)H]-thymidine incorporation into renal DNA. Treatment of rats orally with coumarin (10 mg/kg body weight and 20 mg/kg body weight) resulted in a significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H(2)O(2) generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content (P < 0.01) and antioxidant enzymes were also recovered to significant level (P < 0.001). These results show that coumarin may be used as an effective chemopreventive agent against KBrO(3)-mediated renal oxidative stress, toxicity and tumor promotion response in Wistar rats. SN - 1351-0002 UR - https://www.unboundmedicine.com/medline/citation/15035824/Attenuation_of_potassium_bromate_induced_nephrotoxicity_by_coumarin__12_benzopyrone__in_Wistar_rats:_chemoprevention_against_free_radical_mediated_renal_oxidative_stress_and_tumor_promotion_response_ L2 - https://www.tandfonline.com/doi/full/10.1179/135100004225003860 DB - PRIME DP - Unbound Medicine ER -