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Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes.
J Ethnopharmacol. 2004 Mar; 91(1):109-13.JE

Abstract

The purpose of this study was to investigate the effects of daily oral administration of aqueous solution of Boerhaavia diffusa L. leaf extract (BLEt) (200 mg/kg) for 4 weeks on blood glucose concentration and hepatic enzymes in normal and alloxan induced diabetic rats. A significant decrease in blood glucose and significant increase in plasma insulin levels were observed in normal and diabetic rats treated with BLEt. Treatment with BLEt resulted in a significant reduction of glycosylated haemoglobin and an increase in total haemoglobin level. The activities of the hepatic enzymes such as hexokinase was significantly increased and glucose-6-phosphatase, fructose-1,6-bisphosphatase were significantly decreased by the administration of BLEt in normal and diabetic rats. An oral glucose tolerance test (OGTT) was also performed in the same groups, in which there was a significant improvement in glucose tolerance in rats treated with BLEt. A comparison was made between the action of BLEt and antidiabetic drug-glibenclamide (600 microg/kg). The effect of BLEt was more prominent when compared to glibenclamide.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India. paribala@sancharnet.inNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15036478

Citation

Pari, L, and M Amarnath Satheesh. "Antidiabetic Activity of Boerhaavia Diffusa L.: Effect On Hepatic Key Enzymes in Experimental Diabetes." Journal of Ethnopharmacology, vol. 91, no. 1, 2004, pp. 109-13.
Pari L, Amarnath Satheesh M. Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. J Ethnopharmacol. 2004;91(1):109-13.
Pari, L., & Amarnath Satheesh, M. (2004). Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. Journal of Ethnopharmacology, 91(1), 109-13.
Pari L, Amarnath Satheesh M. Antidiabetic Activity of Boerhaavia Diffusa L.: Effect On Hepatic Key Enzymes in Experimental Diabetes. J Ethnopharmacol. 2004;91(1):109-13. PubMed PMID: 15036478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. AU - Pari,L, AU - Amarnath Satheesh,M, PY - 2002/09/12/received PY - 2003/11/26/revised PY - 2003/12/01/accepted PY - 2004/3/24/pubmed PY - 2004/7/21/medline PY - 2004/3/24/entrez SP - 109 EP - 13 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 91 IS - 1 N2 - The purpose of this study was to investigate the effects of daily oral administration of aqueous solution of Boerhaavia diffusa L. leaf extract (BLEt) (200 mg/kg) for 4 weeks on blood glucose concentration and hepatic enzymes in normal and alloxan induced diabetic rats. A significant decrease in blood glucose and significant increase in plasma insulin levels were observed in normal and diabetic rats treated with BLEt. Treatment with BLEt resulted in a significant reduction of glycosylated haemoglobin and an increase in total haemoglobin level. The activities of the hepatic enzymes such as hexokinase was significantly increased and glucose-6-phosphatase, fructose-1,6-bisphosphatase were significantly decreased by the administration of BLEt in normal and diabetic rats. An oral glucose tolerance test (OGTT) was also performed in the same groups, in which there was a significant improvement in glucose tolerance in rats treated with BLEt. A comparison was made between the action of BLEt and antidiabetic drug-glibenclamide (600 microg/kg). The effect of BLEt was more prominent when compared to glibenclamide. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15036478/Antidiabetic_activity_of_Boerhaavia_diffusa_L_:_effect_on_hepatic_key_enzymes_in_experimental_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378874103004549 DB - PRIME DP - Unbound Medicine ER -