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Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women.
Maturitas 2004; 47(3):185-93M

Abstract

OBJECTIVES

Aim of this study was to evaluate increased body mass index (BMI) as an anthropometric factor, predisposing to lower rates of bone turnover or changes in bone balance after menopause.

MATERIAL AND METHODS

For this purpose, we calculated BMI, and measured spinal (BMD(SP)) and femoral bone mineral density (BMD(FN)) and biochemical markers of bone formation (serum osteocalcin (S-OC), serum procollagen type I C propeptide (S-PICP), serum bone-specific alkaline phosphatase (S-B-ALP)) and resorption (urine N- and C-terminal cross-linking telopeptide of type I collagen (U-NTX-I and U-CTX-I), pyridinoline (U-PYD) and deoxypyridinoline (U-DPD)) in 130 healthy postmenopausal women, aged 46-85 years. Bone balance indices were calculated by subtracting z-scores of resorption markers from z-scores of formation markers, to evaluate bone balance.

RESULTS

S-PICP (r = -0.297, P = 0.002), S-OC (r = -0.173, P = 0.05) and bone balance indices (zPICP-zDPD) and (zPICP-zPYD) were negatively correlated with BMI (r = -0.25, P = 0.01 and r = -0.25, P = 0.01 and r = -0.21, P = 0.037) and with BMD(SP) (r = -0.196, P = 0.032 and r = -0.275 and P = 0.022). Women were grouped according to their BMI, in normals (BMI < 25 kg/m2), overweight (BMI = 25-30 kg/m2, and obese (BMI > 30 kg/m2). Overweight and obese women had approximately 30% lower levels of S-PICP compared to normals (68.11 +/- 24.85 and 66.41 ng/ml versus 97.47 +/- 23.36 ng/ml, respectively; P = 0.0001). zPICP-zDPD, zPICP-zCTX-I and zPICP-zPYD were significantly declined in obese women compared to normals (P = 0.0072, 0.02 and 0.0028).

CONCLUSIONS

We conclude that in postmenopausal women, BMI is inversely associated with levels of collagen I formation marker, serum PICP. In obesity formation of collagen I was reduced, in favor of degradation, but since this finding is not followed by simultaneous decrease in bone mineral density, it seems that increased body weight may have different effects on mature estrogen-deficient bone and extraskeletal tissues containing collagen I.

Authors+Show Affiliations

Center for the Study of Osteoporotic Fractures, University of Crete, Heraklion, Crete, Greece. kdret@her.forthnet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15036488

Citation

Papakitsou, E F., et al. "Body Mass Index (BMI) and Parameters of Bone Formation and Resorption in Postmenopausal Women." Maturitas, vol. 47, no. 3, 2004, pp. 185-93.
Papakitsou EF, Margioris AN, Dretakis KE, et al. Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. Maturitas. 2004;47(3):185-93.
Papakitsou, E. F., Margioris, A. N., Dretakis, K. E., Trovas, G., Zoras, U., Lyritis, G., ... Stergiopoulos, K. (2004). Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. Maturitas, 47(3), pp. 185-93.
Papakitsou EF, et al. Body Mass Index (BMI) and Parameters of Bone Formation and Resorption in Postmenopausal Women. Maturitas. 2004 Mar 15;47(3):185-93. PubMed PMID: 15036488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. AU - Papakitsou,E F, AU - Margioris,A N, AU - Dretakis,K E, AU - Trovas,G, AU - Zoras,U, AU - Lyritis,G, AU - Dretakis,E K, AU - Stergiopoulos,K, PY - 2002/03/19/received PY - 2002/12/04/revised PY - 2002/12/09/accepted PY - 2004/3/24/pubmed PY - 2004/7/9/medline PY - 2004/3/24/entrez SP - 185 EP - 93 JF - Maturitas JO - Maturitas VL - 47 IS - 3 N2 - OBJECTIVES: Aim of this study was to evaluate increased body mass index (BMI) as an anthropometric factor, predisposing to lower rates of bone turnover or changes in bone balance after menopause. MATERIAL AND METHODS: For this purpose, we calculated BMI, and measured spinal (BMD(SP)) and femoral bone mineral density (BMD(FN)) and biochemical markers of bone formation (serum osteocalcin (S-OC), serum procollagen type I C propeptide (S-PICP), serum bone-specific alkaline phosphatase (S-B-ALP)) and resorption (urine N- and C-terminal cross-linking telopeptide of type I collagen (U-NTX-I and U-CTX-I), pyridinoline (U-PYD) and deoxypyridinoline (U-DPD)) in 130 healthy postmenopausal women, aged 46-85 years. Bone balance indices were calculated by subtracting z-scores of resorption markers from z-scores of formation markers, to evaluate bone balance. RESULTS: S-PICP (r = -0.297, P = 0.002), S-OC (r = -0.173, P = 0.05) and bone balance indices (zPICP-zDPD) and (zPICP-zPYD) were negatively correlated with BMI (r = -0.25, P = 0.01 and r = -0.25, P = 0.01 and r = -0.21, P = 0.037) and with BMD(SP) (r = -0.196, P = 0.032 and r = -0.275 and P = 0.022). Women were grouped according to their BMI, in normals (BMI < 25 kg/m2), overweight (BMI = 25-30 kg/m2, and obese (BMI > 30 kg/m2). Overweight and obese women had approximately 30% lower levels of S-PICP compared to normals (68.11 +/- 24.85 and 66.41 ng/ml versus 97.47 +/- 23.36 ng/ml, respectively; P = 0.0001). zPICP-zDPD, zPICP-zCTX-I and zPICP-zPYD were significantly declined in obese women compared to normals (P = 0.0072, 0.02 and 0.0028). CONCLUSIONS: We conclude that in postmenopausal women, BMI is inversely associated with levels of collagen I formation marker, serum PICP. In obesity formation of collagen I was reduced, in favor of degradation, but since this finding is not followed by simultaneous decrease in bone mineral density, it seems that increased body weight may have different effects on mature estrogen-deficient bone and extraskeletal tissues containing collagen I. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/15036488/Body_mass_index__BMI__and_parameters_of_bone_formation_and_resorption_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378512203002822 DB - PRIME DP - Unbound Medicine ER -