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APOE and modulation of Alzheimer's and frontotemporal dementia.
Neurosci Lett 2004; 356(3):167-70NL

Abstract

To investigate the difference in the morphologic expression of frontotemporal dementia (FTD) and Alzheimer's disease (AD) in patients carrying and not carrying the epsilon4 allele of APOE, MR images of 26 controls, 18 AD patients (11 carrying the epsilon4 allele, seven non-carriers), and eight FTD (two carriers, six non-carriers) were compared using voxel by voxel analysis. Greater atrophy was found in the disease-specific regions of the epsilon4 carriers vs the non-carriers at P < 0.05 corrected: medial temporal atrophy was greater in the AD carrying the epsilon4 allele, right ventral striatal atrophy in the FTD carrying the allele. The non-carriers did not have atrophic regions compared to the carriers. The epsilon4 allele of the APOE might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain.

Authors+Show Affiliations

Laboratory of Epidemiology and Neuroimaging (L.E.N.I.), IRCCS San Giovanni di Dio - FBF, Brescia 25125, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15036621

Citation

Boccardi, M, et al. "APOE and Modulation of Alzheimer's and Frontotemporal Dementia." Neuroscience Letters, vol. 356, no. 3, 2004, pp. 167-70.
Boccardi M, Sabattoli F, Testa C, et al. APOE and modulation of Alzheimer's and frontotemporal dementia. Neurosci Lett. 2004;356(3):167-70.
Boccardi, M., Sabattoli, F., Testa, C., Beltramello, A., Soininen, H., & Frisoni, G. B. (2004). APOE and modulation of Alzheimer's and frontotemporal dementia. Neuroscience Letters, 356(3), pp. 167-70.
Boccardi M, et al. APOE and Modulation of Alzheimer's and Frontotemporal Dementia. Neurosci Lett. 2004 Feb 19;356(3):167-70. PubMed PMID: 15036621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - APOE and modulation of Alzheimer's and frontotemporal dementia. AU - Boccardi,M, AU - Sabattoli,F, AU - Testa,C, AU - Beltramello,A, AU - Soininen,H, AU - Frisoni,G B, PY - 2003/07/30/received PY - 2003/11/11/revised PY - 2003/11/18/accepted PY - 2004/3/24/pubmed PY - 2004/5/11/medline PY - 2004/3/24/entrez SP - 167 EP - 70 JF - Neuroscience letters JO - Neurosci. Lett. VL - 356 IS - 3 N2 - To investigate the difference in the morphologic expression of frontotemporal dementia (FTD) and Alzheimer's disease (AD) in patients carrying and not carrying the epsilon4 allele of APOE, MR images of 26 controls, 18 AD patients (11 carrying the epsilon4 allele, seven non-carriers), and eight FTD (two carriers, six non-carriers) were compared using voxel by voxel analysis. Greater atrophy was found in the disease-specific regions of the epsilon4 carriers vs the non-carriers at P < 0.05 corrected: medial temporal atrophy was greater in the AD carrying the epsilon4 allele, right ventral striatal atrophy in the FTD carrying the allele. The non-carriers did not have atrophic regions compared to the carriers. The epsilon4 allele of the APOE might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15036621/APOE_and_modulation_of_Alzheimer's_and_frontotemporal_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394003013703 DB - PRIME DP - Unbound Medicine ER -