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Gestational diabetes and preeclampsia.
Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15; 113(1):12-6.EJ

Abstract

OBJECTIVE

To determine whether gestational diabetes mellitus (GDM) increases the risk for preeclampsia independent of other risk factors.

STUDY DESIGN

The association between GDM and preeclampsia was analyzed in a population of women who had given birth to singletons registered in Swedish Medical Birth Register from 1992 through 1996 (n=430,852).

RESULTS

GDM occurred in 0.8% and preeclampsia in 2.9% of all pregnancies. The rate of preeclampsia was higher in the GDM than in the non-GDM group (6.1% versus 2.8%). High age, nullipara, chronic hypertension, kidney disease, and high body mass index (BMI) were all independently associated with increased risk for preeclampsia. Smoking was associated with decreased risk. Adjusted odds ratio for GDM as a risk factor for preeclampsia was 1.61 (95% confidence interval (CI) 1.39-1.86) when prepregnancy BMI, which was a true confounder, was included in the last step of the multiple logistic regression analysis.

CONCLUSIONS

There is an independent and significant association between GDM and preeclampsia. Obesity is a major confounding factor but could not explain the total excess risk.

Authors+Show Affiliations

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. ingrid.ostlund@orebroll.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15036703

Citation

Ostlund, Ingrid, et al. "Gestational Diabetes and Preeclampsia." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 113, no. 1, 2004, pp. 12-6.
Ostlund I, Haglund B, Hanson U. Gestational diabetes and preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2004;113(1):12-6.
Ostlund, I., Haglund, B., & Hanson, U. (2004). Gestational diabetes and preeclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 113(1), 12-6.
Ostlund I, Haglund B, Hanson U. Gestational Diabetes and Preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15;113(1):12-6. PubMed PMID: 15036703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestational diabetes and preeclampsia. AU - Ostlund,Ingrid, AU - Haglund,Bengt, AU - Hanson,Ulf, PY - 2004/3/24/pubmed PY - 2004/6/18/medline PY - 2004/3/24/entrez SP - 12 EP - 6 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 113 IS - 1 N2 - OBJECTIVE: To determine whether gestational diabetes mellitus (GDM) increases the risk for preeclampsia independent of other risk factors. STUDY DESIGN: The association between GDM and preeclampsia was analyzed in a population of women who had given birth to singletons registered in Swedish Medical Birth Register from 1992 through 1996 (n=430,852). RESULTS: GDM occurred in 0.8% and preeclampsia in 2.9% of all pregnancies. The rate of preeclampsia was higher in the GDM than in the non-GDM group (6.1% versus 2.8%). High age, nullipara, chronic hypertension, kidney disease, and high body mass index (BMI) were all independently associated with increased risk for preeclampsia. Smoking was associated with decreased risk. Adjusted odds ratio for GDM as a risk factor for preeclampsia was 1.61 (95% confidence interval (CI) 1.39-1.86) when prepregnancy BMI, which was a true confounder, was included in the last step of the multiple logistic regression analysis. CONCLUSIONS: There is an independent and significant association between GDM and preeclampsia. Obesity is a major confounding factor but could not explain the total excess risk. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/15036703/Gestational_diabetes_and_preeclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301211503003385 DB - PRIME DP - Unbound Medicine ER -