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Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men.
Diabetes Res Clin Pract 2004; 64(1):59-70DR

Abstract

To determine whether the clustered features of the metabolic syndrome precede the 7 year incidence of cardiovascular disease (CVD) and type 2 diabetes, we examined 6182 Japanese male office workers aged 35-59 years without any history of CVD. The 5588 subjects without type 2 diabetes also constituted the nondiabetic cohort, and were re-examined over seven successive years. Components of the metabolic syndrome included glycemic disorder (type 2 diabetes for the risk of CVD and impaired fasting glucose for the risk of type 2 diabetes), systemic obesity, hypertension, dyslipidemia, proteinuria, and elevated white blood cell (WBC) count. After controlling for age, family history of diabetes, alcohol intake, and cigarette smoking, the multivariate-adjusted relative risk of incidence of CVD compared with absence of components was 3.18, 3.48, 12.55, and 14.15 (P for trend <0.001), for the presence of 1,2,3, and > or =4 components, respectively. The corresponding relative risks of incidence of type 2 diabetes were 1.92, 4.36, 6.44, and 15.08 (P for trend <0.001). In both non-smokers and current smokers, the multivariate-adjusted relative risks of incidence of CVD and type 2 diabetes increased as the number of components increased (P for trend <0.001 for all). Our findings indicate that clustered features of the metabolic syndrome are closely associated with development of CVD and type 2 diabetes in middle-aged Japanese.

Authors+Show Affiliations

Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2-2 Yamada-oka, Suita-shi, Osaka 565-0871, Japan. noriyuki@pbhel.med.osaka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15036828

Citation

Nakanishi, Noriyuki, et al. "Components of the Metabolic Syndrome as Predictors of Cardiovascular Disease and Type 2 Diabetes in Middle-aged Japanese Men." Diabetes Research and Clinical Practice, vol. 64, no. 1, 2004, pp. 59-70.
Nakanishi N, Takatorige T, Fukuda H, et al. Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men. Diabetes Res Clin Pract. 2004;64(1):59-70.
Nakanishi, N., Takatorige, T., Fukuda, H., Shirai, K., Li, W., Okamoto, M., ... Tatara, K. (2004). Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men. Diabetes Research and Clinical Practice, 64(1), pp. 59-70.
Nakanishi N, et al. Components of the Metabolic Syndrome as Predictors of Cardiovascular Disease and Type 2 Diabetes in Middle-aged Japanese Men. Diabetes Res Clin Pract. 2004;64(1):59-70. PubMed PMID: 15036828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men. AU - Nakanishi,Noriyuki, AU - Takatorige,Toshio, AU - Fukuda,Hideki, AU - Shirai,Kokoro, AU - Li,Wenjuan, AU - Okamoto,Mitsuharu, AU - Yoshida,Hiroshi, AU - Matsuo,Yoshio, AU - Suzuki,Kenji, AU - Tatara,Kozo, PY - 2003/04/17/received PY - 2003/07/25/revised PY - 2003/10/09/accepted PY - 2004/3/24/pubmed PY - 2004/12/16/medline PY - 2004/3/24/entrez SP - 59 EP - 70 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 64 IS - 1 N2 - To determine whether the clustered features of the metabolic syndrome precede the 7 year incidence of cardiovascular disease (CVD) and type 2 diabetes, we examined 6182 Japanese male office workers aged 35-59 years without any history of CVD. The 5588 subjects without type 2 diabetes also constituted the nondiabetic cohort, and were re-examined over seven successive years. Components of the metabolic syndrome included glycemic disorder (type 2 diabetes for the risk of CVD and impaired fasting glucose for the risk of type 2 diabetes), systemic obesity, hypertension, dyslipidemia, proteinuria, and elevated white blood cell (WBC) count. After controlling for age, family history of diabetes, alcohol intake, and cigarette smoking, the multivariate-adjusted relative risk of incidence of CVD compared with absence of components was 3.18, 3.48, 12.55, and 14.15 (P for trend <0.001), for the presence of 1,2,3, and > or =4 components, respectively. The corresponding relative risks of incidence of type 2 diabetes were 1.92, 4.36, 6.44, and 15.08 (P for trend <0.001). In both non-smokers and current smokers, the multivariate-adjusted relative risks of incidence of CVD and type 2 diabetes increased as the number of components increased (P for trend <0.001 for all). Our findings indicate that clustered features of the metabolic syndrome are closely associated with development of CVD and type 2 diabetes in middle-aged Japanese. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/15036828/Components_of_the_metabolic_syndrome_as_predictors_of_cardiovascular_disease_and_type_2_diabetes_in_middle_aged_Japanese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168822703002572 DB - PRIME DP - Unbound Medicine ER -