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Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases.

Abstract

Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. Some of the chemically and metabolically stable oxidation products are useful in vivo biomarkers of lipid peroxidation. These include the isoprostanes (IsoPs) and isofurans (IsoFs), derived from arachidonic acid (AA), and neuroprostanes (NeuroPs), derived from docosahexaenoic acid (DHA). We have shown increased levels of IsoPs, NeuroPs, and IsoFs in diseased regions of brain from patients who died from advanced Alzheimer's disease (AD) or Parkinson's disease (PD). Increased cerebrospinal fluid (CSF) levels of IsoPs are present in patients with AD or Huntington's disease (HD) early in the course of their illness, and CSF IsoPs may improve the laboratory diagnostic accuracy for AD. In contrast, quantification of IsoPs in plasma and urine of AD patients has yielded inconsistent results. These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD.

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  • Authors+Show Affiliations

    ,

    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, 325 9th Ave., Seattle, WA 98104, USA.

    , , , , ,

    Source

    Chemistry and physics of lipids 128:1-2 2004 Mar pg 117-24

    MeSH

    Alzheimer Disease
    Humans
    Isoprostanes
    Lipid Peroxidation
    Parkinson Disease

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    15037157

    Citation

    Montine, Kathleen S., et al. "Isoprostanes and Related Products of Lipid Peroxidation in Neurodegenerative Diseases." Chemistry and Physics of Lipids, vol. 128, no. 1-2, 2004, pp. 117-24.
    Montine KS, Quinn JF, Zhang J, et al. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids. 2004;128(1-2):117-24.
    Montine, K. S., Quinn, J. F., Zhang, J., Fessel, J. P., Roberts, L. J., Morrow, J. D., & Montine, T. J. (2004). Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chemistry and Physics of Lipids, 128(1-2), pp. 117-24.
    Montine KS, et al. Isoprostanes and Related Products of Lipid Peroxidation in Neurodegenerative Diseases. Chem Phys Lipids. 2004;128(1-2):117-24. PubMed PMID: 15037157.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. AU - Montine,Kathleen S, AU - Quinn,Joseph F, AU - Zhang,Jing, AU - Fessel,Joshua P, AU - Roberts,L Jackson,2nd AU - Morrow,Jason D, AU - Montine,Thomas J, PY - 2004/3/24/pubmed PY - 2004/6/21/medline PY - 2004/3/24/entrez SP - 117 EP - 24 JF - Chemistry and physics of lipids JO - Chem. Phys. Lipids VL - 128 IS - 1-2 N2 - Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. Some of the chemically and metabolically stable oxidation products are useful in vivo biomarkers of lipid peroxidation. These include the isoprostanes (IsoPs) and isofurans (IsoFs), derived from arachidonic acid (AA), and neuroprostanes (NeuroPs), derived from docosahexaenoic acid (DHA). We have shown increased levels of IsoPs, NeuroPs, and IsoFs in diseased regions of brain from patients who died from advanced Alzheimer's disease (AD) or Parkinson's disease (PD). Increased cerebrospinal fluid (CSF) levels of IsoPs are present in patients with AD or Huntington's disease (HD) early in the course of their illness, and CSF IsoPs may improve the laboratory diagnostic accuracy for AD. In contrast, quantification of IsoPs in plasma and urine of AD patients has yielded inconsistent results. These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD. SN - 0009-3084 UR - https://www.unboundmedicine.com/medline/citation/15037157/Isoprostanes_and_related_products_of_lipid_peroxidation_in_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009308403001592 DB - PRIME DP - Unbound Medicine ER -