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Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia.
Schizophr Res 2004; 68(1):65-73SR

Abstract

Frontal lobe dysfunction in individuals with schizophrenia has frequently been detected using both neuroimaging and neuropsychological testing. Results from previous studies vary in the findings of regional specificity vs. generalized frontal cortical dysfunction. We sought to examine potential regional differences in frontal cortical functioning among patients with schizophrenia vs. a comparison group using two different neurocognitive tasks: the Gambling Task (GT) and the Wisconsin Card Sorting Test (WCST). In general, the GT is thought to reflect function of the ventromedial prefrontal cortex (VMPFC), while the WCST reflects function of the dorsolateral prefrontal cortex (DLPFC). Twenty individuals with schizophrenia or schizoaffective disorder and 15 nonpsychiatrically ill comparison subjects underwent an assessment battery consisting of the GT, WCST, and positive and negative symptom ratings. Patients with schizophrenia performed worse on the GT with respect to total monetary gain (p=0.05) and total monetary loss (p<0.05). They also preferred disadvantaged vs. advantaged cards (p<0.04). Surprisingly, WCST performance was poor in both groups and was not significantly different between groups. These findings are at some variance with those in the previously reported literature, but nonetheless support the idea that prefrontal cortical areas mediating different cognitive tasks may be distinguished by specific neurocognitive assessments.

Authors+Show Affiliations

Psychiatry Service, VA Ann Arbor Health Care System, Ann Arbor, MI 48105, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15037340

Citation

Ritter, Laura M., et al. "Neurocognitive Measures of Prefrontal Cortical Dysfunction in Schizophrenia." Schizophrenia Research, vol. 68, no. 1, 2004, pp. 65-73.
Ritter LM, Meador-Woodruff JH, Dalack GW. Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizophr Res. 2004;68(1):65-73.
Ritter, L. M., Meador-Woodruff, J. H., & Dalack, G. W. (2004). Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizophrenia Research, 68(1), pp. 65-73.
Ritter LM, Meador-Woodruff JH, Dalack GW. Neurocognitive Measures of Prefrontal Cortical Dysfunction in Schizophrenia. Schizophr Res. 2004 May 1;68(1):65-73. PubMed PMID: 15037340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. AU - Ritter,Laura M, AU - Meador-Woodruff,James H, AU - Dalack,Gregory W, PY - 2002/09/04/received PY - 2003/02/18/revised PY - 2003/02/26/accepted PY - 2004/3/24/pubmed PY - 2004/7/28/medline PY - 2004/3/24/entrez SP - 65 EP - 73 JF - Schizophrenia research JO - Schizophr. Res. VL - 68 IS - 1 N2 - Frontal lobe dysfunction in individuals with schizophrenia has frequently been detected using both neuroimaging and neuropsychological testing. Results from previous studies vary in the findings of regional specificity vs. generalized frontal cortical dysfunction. We sought to examine potential regional differences in frontal cortical functioning among patients with schizophrenia vs. a comparison group using two different neurocognitive tasks: the Gambling Task (GT) and the Wisconsin Card Sorting Test (WCST). In general, the GT is thought to reflect function of the ventromedial prefrontal cortex (VMPFC), while the WCST reflects function of the dorsolateral prefrontal cortex (DLPFC). Twenty individuals with schizophrenia or schizoaffective disorder and 15 nonpsychiatrically ill comparison subjects underwent an assessment battery consisting of the GT, WCST, and positive and negative symptom ratings. Patients with schizophrenia performed worse on the GT with respect to total monetary gain (p=0.05) and total monetary loss (p<0.05). They also preferred disadvantaged vs. advantaged cards (p<0.04). Surprisingly, WCST performance was poor in both groups and was not significantly different between groups. These findings are at some variance with those in the previously reported literature, but nonetheless support the idea that prefrontal cortical areas mediating different cognitive tasks may be distinguished by specific neurocognitive assessments. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/15037340/Neurocognitive_measures_of_prefrontal_cortical_dysfunction_in_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920996403000860 DB - PRIME DP - Unbound Medicine ER -