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Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study.
Eur Heart J. 2004 Mar; 25(6):492-9.EH

Abstract

BACKGROUND

Depression is associated with an increase in cardiovascular disease, but the underlying mechanisms are not well understood. The aim of this study was to examine the associations of depressive symptoms with inflammation and coagulation factors related to cardiovascular risk in persons free of cardiovascular disease.

METHODS

A random algorithm was developed and stratified by gender-age and multistage sampling was performed during 2001-2002. In this study, we analysed data from 453 men (19-89 years old) and 400 women (18-84 years old). Inflammation markers were C-reactive protein (CRP), serum amyloid A, white blood cell (WBC) and total platelet counts; and coagulation factors including homocysteine and fibrinogen. Depression was assessed with the Zung Self-Rating Depression Scale (ZDRS range 0-100) after validation for the study population. A ZDRS score of 50 or more classified a person as mildly depressive. Statistical adjustments were made for risk factors (age, gender, smoking, diabetes mellitus, and physical activity level).

RESULTS

Women had significantly higher scores on the Zung depression scale than men (47 +/- 9 vs. 43 +/- 10, p<0.001). Thus, 21% of men and 27% of women had mild depression, while 4% of men and 6% of women had severe depressive symptomatology. The depression scale correlated positively with C-reactive protein levels (p<0.05), white blood cell count (p<0.05), and fibrinogen (p<0.05) in both genders after adjustment for control variables.

CONCLUSION

This study revealed that depression was associated with inflammation and coagulation factors in cardiovascular disease-free people, suggesting a possible pathway leading to an increased frequency of events of coronary heart disease in depressive individuals.

Authors+Show Affiliations

Department of Dietetics and Nutrition, Harokopio University, Athens, Greece. d.b.panagiotakos@usa.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15039129

Citation

Panagiotakos, Demosthenes B., et al. "Inflammation, Coagulation, and Depressive Symptomatology in Cardiovascular Disease-free People; the ATTICA Study." European Heart Journal, vol. 25, no. 6, 2004, pp. 492-9.
Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. Eur Heart J. 2004;25(6):492-9.
Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Tsetsekou, E., Papageorgiou, C., Christodoulou, G., & Stefanadis, C. (2004). Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. European Heart Journal, 25(6), 492-9.
Panagiotakos DB, et al. Inflammation, Coagulation, and Depressive Symptomatology in Cardiovascular Disease-free People; the ATTICA Study. Eur Heart J. 2004;25(6):492-9. PubMed PMID: 15039129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. AU - Panagiotakos,Demosthenes B, AU - Pitsavos,Christos, AU - Chrysohoou,Christina, AU - Tsetsekou,Efi, AU - Papageorgiou,Charalambos, AU - Christodoulou,George, AU - Stefanadis,Christodoulos, AU - ,, PY - 2003/09/25/received PY - 2004/01/15/revised PY - 2004/01/22/accepted PY - 2004/3/25/pubmed PY - 2004/7/28/medline PY - 2004/3/25/entrez SP - 492 EP - 9 JF - European heart journal JO - Eur. Heart J. VL - 25 IS - 6 N2 - BACKGROUND: Depression is associated with an increase in cardiovascular disease, but the underlying mechanisms are not well understood. The aim of this study was to examine the associations of depressive symptoms with inflammation and coagulation factors related to cardiovascular risk in persons free of cardiovascular disease. METHODS: A random algorithm was developed and stratified by gender-age and multistage sampling was performed during 2001-2002. In this study, we analysed data from 453 men (19-89 years old) and 400 women (18-84 years old). Inflammation markers were C-reactive protein (CRP), serum amyloid A, white blood cell (WBC) and total platelet counts; and coagulation factors including homocysteine and fibrinogen. Depression was assessed with the Zung Self-Rating Depression Scale (ZDRS range 0-100) after validation for the study population. A ZDRS score of 50 or more classified a person as mildly depressive. Statistical adjustments were made for risk factors (age, gender, smoking, diabetes mellitus, and physical activity level). RESULTS: Women had significantly higher scores on the Zung depression scale than men (47 +/- 9 vs. 43 +/- 10, p<0.001). Thus, 21% of men and 27% of women had mild depression, while 4% of men and 6% of women had severe depressive symptomatology. The depression scale correlated positively with C-reactive protein levels (p<0.05), white blood cell count (p<0.05), and fibrinogen (p<0.05) in both genders after adjustment for control variables. CONCLUSION: This study revealed that depression was associated with inflammation and coagulation factors in cardiovascular disease-free people, suggesting a possible pathway leading to an increased frequency of events of coronary heart disease in depressive individuals. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/15039129/Inflammation_coagulation_and_depressive_symptomatology_in_cardiovascular_disease_free_people L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1016/j.ehj.2004.01.018 DB - PRIME DP - Unbound Medicine ER -