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Inhibiting sexual transmission of HIV-1 infection.
Nat Rev Microbiol. 2003 Oct; 1(1):25-34.NR

Abstract

The worldwide infection rate for HIV-1 is estimated to be 14,000 per day, but only now, more than 20 years into the epidemic, are the immediate events between exposure to infectious virus and the establishment of infection becoming clear. Defining the mechanisms of HIV-1 transmission, the target cells involved and how the virus attaches to and fuses with these cells, could reveal ways to block the sexual spread of the virus. In this review, we will discuss how our increasing knowledge of the ways in which HIV-1 is transmitted is shaping the development of new, more sophisticated intervention strategies based on the application of vaginal or rectal microbicides.

Authors+Show Affiliations

Shattock RJ
Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, UK. Shattock@sghms.ac.uk
Moore JP
No affiliation info available

MeSH

Administration, IntravaginalAdministration, RectalAnimalsAnti-HIV AgentsAnti-Infective AgentsDisease Transmission, InfectiousDrug Delivery SystemsEpithelial CellsFemaleGene Products, envHIV Fusion InhibitorsHIV InfectionsHIV-1HumansMaleRectumVagina

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15040177

Citation

Shattock, Robin J., and John P. Moore. "Inhibiting Sexual Transmission of HIV-1 Infection." Nature Reviews. Microbiology, vol. 1, no. 1, 2003, pp. 25-34.
Shattock RJ, Moore JP. Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol. 2003;1(1):25-34.
Shattock, R. J., & Moore, J. P. (2003). Inhibiting sexual transmission of HIV-1 infection. Nature Reviews. Microbiology, 1(1), 25-34.
Shattock RJ, Moore JP. Inhibiting Sexual Transmission of HIV-1 Infection. Nat Rev Microbiol. 2003;1(1):25-34. PubMed PMID: 15040177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibiting sexual transmission of HIV-1 infection. AU - Shattock,Robin J, AU - Moore,John P, PY - 2004/3/26/pubmed PY - 2004/4/28/medline PY - 2004/3/26/entrez SP - 25 EP - 34 JF - Nature reviews. Microbiology JO - Nat Rev Microbiol VL - 1 IS - 1 N2 - The worldwide infection rate for HIV-1 is estimated to be 14,000 per day, but only now, more than 20 years into the epidemic, are the immediate events between exposure to infectious virus and the establishment of infection becoming clear. Defining the mechanisms of HIV-1 transmission, the target cells involved and how the virus attaches to and fuses with these cells, could reveal ways to block the sexual spread of the virus. In this review, we will discuss how our increasing knowledge of the ways in which HIV-1 is transmitted is shaping the development of new, more sophisticated intervention strategies based on the application of vaginal or rectal microbicides. SN - 1740-1526 UR - https://www.unboundmedicine.com/medline/citation/15040177/Inhibiting_sexual_transmission_of_HIV_1_infection_ DB - PRIME DP - Unbound Medicine ER -