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Diclofenac sodium loaded gelatin magnetic microspheres for intra-arterial administration: formulation, characterization and in vitro release studies.
Boll Chim Farm. 2003 Oct; 142(8):347-51.BC

Abstract

Gelatin magnetic microspheres loaded with diclofenac sodium were prepared by emulsification and crosslinking by glutaraldehyde. The microspheres were formulated with 23-30% theoretical diclofenac sodium and magnetite content. The formulated microspheres were characterized by drug loading, entrapment efficiency, encapsulation efficiency, magnetite content, FT-IR spectroscopy, particle size analysis, optical microscopy, scanning electron microscopy, and in vitro release studies. The data obtained from the in vitro release studies were applied to various kinetic models. The FT-IR revealed no drug/polymer interaction. The average particle size was between 36 to 61 microm depending on quantity of magnetite and gelatin used. Optical microscopy and SEM showed spherical and compact nature of microspheres. The formulated microspheres released the drug for a period of 42 to 78 hours depending on drug loading. The release was diffusion controlled at lower drug loading and dissolution/diffusion controlled at higher drug loading.

Authors+Show Affiliations

Department of Pharmaceutics, Vel's College of Pharmacy, Old Pallavaram, Chennai, Tamilnadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15040465

Citation

Saravanan, M, et al. "Diclofenac Sodium Loaded Gelatin Magnetic Microspheres for Intra-arterial Administration: Formulation, Characterization and in Vitro Release Studies." Bollettino Chimico Farmaceutico, vol. 142, no. 8, 2003, pp. 347-51.
Saravanan M, Bhaskar K, Narayanan NV, et al. Diclofenac sodium loaded gelatin magnetic microspheres for intra-arterial administration: formulation, characterization and in vitro release studies. Boll Chim Farm. 2003;142(8):347-51.
Saravanan, M., Bhaskar, K., Narayanan, N. V., Maharajan, G., & Pillai, K. S. (2003). Diclofenac sodium loaded gelatin magnetic microspheres for intra-arterial administration: formulation, characterization and in vitro release studies. Bollettino Chimico Farmaceutico, 142(8), 347-51.
Saravanan M, et al. Diclofenac Sodium Loaded Gelatin Magnetic Microspheres for Intra-arterial Administration: Formulation, Characterization and in Vitro Release Studies. Boll Chim Farm. 2003;142(8):347-51. PubMed PMID: 15040465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diclofenac sodium loaded gelatin magnetic microspheres for intra-arterial administration: formulation, characterization and in vitro release studies. AU - Saravanan,M, AU - Bhaskar,K, AU - Narayanan,N V S, AU - Maharajan,G, AU - Pillai,K S, PY - 2004/3/26/pubmed PY - 2004/4/20/medline PY - 2004/3/26/entrez SP - 347 EP - 51 JF - Bollettino chimico farmaceutico JO - Boll Chim Farm VL - 142 IS - 8 N2 - Gelatin magnetic microspheres loaded with diclofenac sodium were prepared by emulsification and crosslinking by glutaraldehyde. The microspheres were formulated with 23-30% theoretical diclofenac sodium and magnetite content. The formulated microspheres were characterized by drug loading, entrapment efficiency, encapsulation efficiency, magnetite content, FT-IR spectroscopy, particle size analysis, optical microscopy, scanning electron microscopy, and in vitro release studies. The data obtained from the in vitro release studies were applied to various kinetic models. The FT-IR revealed no drug/polymer interaction. The average particle size was between 36 to 61 microm depending on quantity of magnetite and gelatin used. Optical microscopy and SEM showed spherical and compact nature of microspheres. The formulated microspheres released the drug for a period of 42 to 78 hours depending on drug loading. The release was diffusion controlled at lower drug loading and dissolution/diffusion controlled at higher drug loading. SN - 0006-6648 UR - https://www.unboundmedicine.com/medline/citation/15040465/Diclofenac_sodium_loaded_gelatin_magnetic_microspheres_for_intra_arterial_administration:_formulation_characterization_and_in_vitro_release_studies_ DB - PRIME DP - Unbound Medicine ER -