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Pattern of bacillary clearance in multibacillary leprosy patients with multidrug therapy.
Acta Leprol. 2003; 12(3):123-8.AL

Abstract

The bacteriological index (BI) of the skin smears is traditionally one of the important parameters of assessment of severity and of progress of leprosy under multidrug therapy. The present study reports on BI clearance among 578 multibacillary treated leprosy patients and the factors that influence this clearance. The patients were treated till smear negativity or for 2 years fixed duration and their skin smears periodically examined every 6 to 12 months till negativity (and even afterwards). We confirm that bacterial clearance is a slow process. The time taken for each log-unit decline in BI is between 13.6 to 24 months probably depending on initial BI level. The rate of smear negativity appears to be dependent on immune competence of the patients as reflected by a rapid BI decline in borderline BT-BB patients vis-à-vis BL-LL lepromatous patients both in the low and high BI group. Patients who had several episodes of ENL, took significantly longer time (63.7 months versus 53.5 months, p<0.0001) to become smear negative than those without ENL.

Authors+Show Affiliations

Department of Epidemiology & Biostatistics, CENTRAL Jalma Institute for Leprosy, Taj Ganj, Agra, U.P., India-282001. biostat@sancharnet.inNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15040703

Citation

Kumar, A, et al. "Pattern of Bacillary Clearance in Multibacillary Leprosy Patients With Multidrug Therapy." Acta Leprologica, vol. 12, no. 3, 2003, pp. 123-8.
Kumar A, Girdhar A, Girdhar BK. Pattern of bacillary clearance in multibacillary leprosy patients with multidrug therapy. Acta Leprol. 2003;12(3):123-8.
Kumar, A., Girdhar, A., & Girdhar, B. K. (2003). Pattern of bacillary clearance in multibacillary leprosy patients with multidrug therapy. Acta Leprologica, 12(3), 123-8.
Kumar A, Girdhar A, Girdhar BK. Pattern of Bacillary Clearance in Multibacillary Leprosy Patients With Multidrug Therapy. Acta Leprol. 2003;12(3):123-8. PubMed PMID: 15040703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pattern of bacillary clearance in multibacillary leprosy patients with multidrug therapy. AU - Kumar,A, AU - Girdhar,A, AU - Girdhar,B K, PY - 2004/3/26/pubmed PY - 2004/9/17/medline PY - 2004/3/26/entrez SP - 123 EP - 8 JF - Acta leprologica JO - Acta Leprol VL - 12 IS - 3 N2 - The bacteriological index (BI) of the skin smears is traditionally one of the important parameters of assessment of severity and of progress of leprosy under multidrug therapy. The present study reports on BI clearance among 578 multibacillary treated leprosy patients and the factors that influence this clearance. The patients were treated till smear negativity or for 2 years fixed duration and their skin smears periodically examined every 6 to 12 months till negativity (and even afterwards). We confirm that bacterial clearance is a slow process. The time taken for each log-unit decline in BI is between 13.6 to 24 months probably depending on initial BI level. The rate of smear negativity appears to be dependent on immune competence of the patients as reflected by a rapid BI decline in borderline BT-BB patients vis-à-vis BL-LL lepromatous patients both in the low and high BI group. Patients who had several episodes of ENL, took significantly longer time (63.7 months versus 53.5 months, p<0.0001) to become smear negative than those without ENL. SN - 0001-5938 UR - https://www.unboundmedicine.com/medline/citation/15040703/Pattern_of_bacillary_clearance_in_multibacillary_leprosy_patients_with_multidrug_therapy_ DB - PRIME DP - Unbound Medicine ER -