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NADPH activates a decarboxylation reaction catalysed by lamb liver 6-phosphogluconate dehydrogenase.
Biochim Biophys Acta. 1992 Aug 21; 1122(3):273-7.BB

Abstract

NADP-dependent lamb liver 6-phosphogluconate dehydrogenase catalyses the oxidative decarboxylation of 2-deoxy-6-phosphogluconate, an analogue of the natural substrate. The first products of the reaction are NADPH and 3-keto-2-deoxy-6-phosphogluconate. The NADPH, released from the enzyme, binds to the coenzyme site of the same or the other subunit, activating the decarboxylation reaction in which has not a redox role, since it can be substituted by an analogue devoid of enzymatic redox power. These findings are compared to those obtained with other NADP-dependent decarboxylating dehydrogenases.

Authors+Show Affiliations

Istituto di Chimica Biologica, Università, Ferrara, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1504088

Citation

Hanau, S, et al. "NADPH Activates a Decarboxylation Reaction Catalysed By Lamb Liver 6-phosphogluconate Dehydrogenase." Biochimica Et Biophysica Acta, vol. 1122, no. 3, 1992, pp. 273-7.
Hanau S, Dallocchio F, Rippa M. NADPH activates a decarboxylation reaction catalysed by lamb liver 6-phosphogluconate dehydrogenase. Biochim Biophys Acta. 1992;1122(3):273-7.
Hanau, S., Dallocchio, F., & Rippa, M. (1992). NADPH activates a decarboxylation reaction catalysed by lamb liver 6-phosphogluconate dehydrogenase. Biochimica Et Biophysica Acta, 1122(3), 273-7.
Hanau S, Dallocchio F, Rippa M. NADPH Activates a Decarboxylation Reaction Catalysed By Lamb Liver 6-phosphogluconate Dehydrogenase. Biochim Biophys Acta. 1992 Aug 21;1122(3):273-7. PubMed PMID: 1504088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NADPH activates a decarboxylation reaction catalysed by lamb liver 6-phosphogluconate dehydrogenase. AU - Hanau,S, AU - Dallocchio,F, AU - Rippa,M, PY - 1992/8/21/pubmed PY - 1992/8/21/medline PY - 1992/8/21/entrez SP - 273 EP - 7 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1122 IS - 3 N2 - NADP-dependent lamb liver 6-phosphogluconate dehydrogenase catalyses the oxidative decarboxylation of 2-deoxy-6-phosphogluconate, an analogue of the natural substrate. The first products of the reaction are NADPH and 3-keto-2-deoxy-6-phosphogluconate. The NADPH, released from the enzyme, binds to the coenzyme site of the same or the other subunit, activating the decarboxylation reaction in which has not a redox role, since it can be substituted by an analogue devoid of enzymatic redox power. These findings are compared to those obtained with other NADP-dependent decarboxylating dehydrogenases. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/1504088/NADPH_activates_a_decarboxylation_reaction_catalysed_by_lamb_liver_6_phosphogluconate_dehydrogenase_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0167-4838(92)90404-2 DB - PRIME DP - Unbound Medicine ER -