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Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
Life Sci. 2004 Apr 09; 74(21):2619-26.LS

Abstract

The inoculation of mice with herpes simplex virus type-1 (HSV-1) causes herpes zoster-like skin lesions and pain-related responses (tactile allodynia and mechanical hyperalgesia) from day 5 after inoculation. Skin lesions completely heal by day 15 after inoculation, but about half of mice with acute herpetic pain show pain-related responses long after the lesions heal. Using this mouse model, we examined the effects of repeated administration of gabapentin and amitriptyline on the acute herpetic pain and the incidence of postherpetic pain. Gabapentin and amitriptyline were administered three times daily from day 5 to 11 after inoculation. Postherpetic pain-related responses were assessed on day 30 after inoculation. Gabapentin (10-100 mg/kg) produced the dose-dependent inhibition of acute herpetic pain-related responses. This medication produced marked reduction in the incidence of delayed postherpetic pain and the dose of 100 mg/kg produced the complete inhibition. Amitriptyline (10 mg/kg) did not affect the acute pain-related responses in the initial 3- and 2-day periods and then gradually inhibited them. This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses. Amitriptyline (1 and 3 mg/kg) was without effects on acute herpetic and postherpetic pain-related responses. The results strongly support the idea that the severity of the acute herpetic pain is a risk factor of postherpetic neuralgia. It may be worth testing the effects of gabapentin on acute herpetic pain and the incidence of postherpetic neuralgia in human subjects.

Authors+Show Affiliations

Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. kiraisiy@ms.toyama-mpu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15041444

Citation

Kuraishi, Yasushi, et al. "Effects of the Suppression of Acute Herpetic Pain By Gabapentin and Amitriptyline On the Incidence of Delayed Postherpetic Pain in Mice." Life Sciences, vol. 74, no. 21, 2004, pp. 2619-26.
Kuraishi Y, Takasaki I, Nojima H, et al. Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. Life Sci. 2004;74(21):2619-26.
Kuraishi, Y., Takasaki, I., Nojima, H., Shiraki, K., & Takahata, H. (2004). Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. Life Sciences, 74(21), 2619-26.
Kuraishi Y, et al. Effects of the Suppression of Acute Herpetic Pain By Gabapentin and Amitriptyline On the Incidence of Delayed Postherpetic Pain in Mice. Life Sci. 2004 Apr 9;74(21):2619-26. PubMed PMID: 15041444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. AU - Kuraishi,Yasushi, AU - Takasaki,Ichiro, AU - Nojima,Hiroshi, AU - Shiraki,Kimiyasu, AU - Takahata,Hiroki, PY - 2004/3/26/pubmed PY - 2004/5/11/medline PY - 2004/3/26/entrez SP - 2619 EP - 26 JF - Life sciences JO - Life Sci. VL - 74 IS - 21 N2 - The inoculation of mice with herpes simplex virus type-1 (HSV-1) causes herpes zoster-like skin lesions and pain-related responses (tactile allodynia and mechanical hyperalgesia) from day 5 after inoculation. Skin lesions completely heal by day 15 after inoculation, but about half of mice with acute herpetic pain show pain-related responses long after the lesions heal. Using this mouse model, we examined the effects of repeated administration of gabapentin and amitriptyline on the acute herpetic pain and the incidence of postherpetic pain. Gabapentin and amitriptyline were administered three times daily from day 5 to 11 after inoculation. Postherpetic pain-related responses were assessed on day 30 after inoculation. Gabapentin (10-100 mg/kg) produced the dose-dependent inhibition of acute herpetic pain-related responses. This medication produced marked reduction in the incidence of delayed postherpetic pain and the dose of 100 mg/kg produced the complete inhibition. Amitriptyline (10 mg/kg) did not affect the acute pain-related responses in the initial 3- and 2-day periods and then gradually inhibited them. This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses. Amitriptyline (1 and 3 mg/kg) was without effects on acute herpetic and postherpetic pain-related responses. The results strongly support the idea that the severity of the acute herpetic pain is a risk factor of postherpetic neuralgia. It may be worth testing the effects of gabapentin on acute herpetic pain and the incidence of postherpetic neuralgia in human subjects. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/15041444/Effects_of_the_suppression_of_acute_herpetic_pain_by_gabapentin_and_amitriptyline_on_the_incidence_of_delayed_postherpetic_pain_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024320504000189 DB - PRIME DP - Unbound Medicine ER -