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Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease.
Am J Kidney Dis. 2004 Apr; 43(4):607-16.AJ

Abstract

BACKGROUND

Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease.

METHODS

We studied 26 adults (age, 65 +/- 10 [SD] years) with chronic kidney disease, not on dialysis therapy. Subjects were randomly assigned to resistance training (n = 14) or a control group (n = 12) for 12 weeks, while counseled to consume a low-protein diet (protein, approximately 0.6 g/kg/d). We determined whether resistance training reduces levels of inflammatory mediators (serum C-reactive protein [CRP] and interleukin-6 [IL-6]), in addition to previously reported improvements in nutritional and functional status in this same subject population.

RESULTS

Serum CRP levels were reduced in subjects undergoing resistance training (-1.7 mg/L) compared with controls (1.5 mg/L; P = 0.05). Similarly, IL-6 levels were reduced in the resistance-exercise group versus controls (-4.2 versus 2.3 pg/mL; P = 0.01). Resistance training lead to skeletal muscle hypertrophy, shown by increases in type I (24% +/- 31%) and type II (22% +/- 41%) muscle fiber cross-sectional areas, compared with control subjects (-14% +/- 34% and -13% +/- 18%, respectively; P < 0.05). Muscle strength also improved with resistance training (28% +/- 14%) compared with controls (-13% +/- 22%; P = 0.001).

CONCLUSION

Resistance training reduced inflammation and improved nutritional status in individuals with moderate chronic kidney disease consuming a low-protein diet. These results need to be investigated further in larger cohorts of patients with varying stages of kidney disease to determine whether resistance training can improve disease outcomes long term.

Authors+Show Affiliations

Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. carmen.sceppa@tufts.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15042537

Citation

Castaneda, Carmen, et al. "Resistance Training to Reduce the Malnutrition-inflammation Complex Syndrome of Chronic Kidney Disease." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 43, no. 4, 2004, pp. 607-16.
Castaneda C, Gordon PL, Parker RC, et al. Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease. Am J Kidney Dis. 2004;43(4):607-16.
Castaneda, C., Gordon, P. L., Parker, R. C., Uhlin, K. L., Roubenoff, R., & Levey, A. S. (2004). Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 43(4), 607-16.
Castaneda C, et al. Resistance Training to Reduce the Malnutrition-inflammation Complex Syndrome of Chronic Kidney Disease. Am J Kidney Dis. 2004;43(4):607-16. PubMed PMID: 15042537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease. AU - Castaneda,Carmen, AU - Gordon,Patricia L, AU - Parker,Russell C, AU - Uhlin,Katherine Leigh, AU - Roubenoff,Ronenn, AU - Levey,Andrew S, PY - 2004/3/26/pubmed PY - 2004/6/17/medline PY - 2004/3/26/entrez SP - 607 EP - 16 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 43 IS - 4 N2 - BACKGROUND: Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease. METHODS: We studied 26 adults (age, 65 +/- 10 [SD] years) with chronic kidney disease, not on dialysis therapy. Subjects were randomly assigned to resistance training (n = 14) or a control group (n = 12) for 12 weeks, while counseled to consume a low-protein diet (protein, approximately 0.6 g/kg/d). We determined whether resistance training reduces levels of inflammatory mediators (serum C-reactive protein [CRP] and interleukin-6 [IL-6]), in addition to previously reported improvements in nutritional and functional status in this same subject population. RESULTS: Serum CRP levels were reduced in subjects undergoing resistance training (-1.7 mg/L) compared with controls (1.5 mg/L; P = 0.05). Similarly, IL-6 levels were reduced in the resistance-exercise group versus controls (-4.2 versus 2.3 pg/mL; P = 0.01). Resistance training lead to skeletal muscle hypertrophy, shown by increases in type I (24% +/- 31%) and type II (22% +/- 41%) muscle fiber cross-sectional areas, compared with control subjects (-14% +/- 34% and -13% +/- 18%, respectively; P < 0.05). Muscle strength also improved with resistance training (28% +/- 14%) compared with controls (-13% +/- 22%; P = 0.001). CONCLUSION: Resistance training reduced inflammation and improved nutritional status in individuals with moderate chronic kidney disease consuming a low-protein diet. These results need to be investigated further in larger cohorts of patients with varying stages of kidney disease to determine whether resistance training can improve disease outcomes long term. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/15042537/Resistance_training_to_reduce_the_malnutrition_inflammation_complex_syndrome_of_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272638604000046 DB - PRIME DP - Unbound Medicine ER -