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X-chromosome loss of heterozygosity frequently occurs in gastrinomas and is correlated with aggressive tumor growth.
Cancer. 2004 Apr 01; 100(7):1379-87.C

Abstract

BACKGROUND

Recent studies have shown that tumor growth, rather than hormone overproduction, is the leading cause of death among patients with gastrinomas and other malignant gastrointestinal endocrine tumors. No patient/laboratory characteristics accurately predict which tumors will exhibit aggressive growth. Furthermore, little is known regarding the molecular pathogenesis of these tumors. X-chromosome loss of heterozygosity (LOH) occurs in some nonendocrine tumors, and its presence can be associated with aggressive growth/decreased survival. Data on X-chromosome LOH in gastrointestinal endocrine tumors are conflicting. Therefore, the purpose of the current study was to determine whether X-chromosome LOH occurred in gastrinomas and, if so, whether it was correlated with tumor growth, tumor behavior, and/or prognosis.

METHODS

X chromosome allelotyping was performed using 12 microsatellite markers spaced throughout the chromosome using DNA from leukocytes and microdissected gastrinoma specimens from 16 female patients. The presence of X-chromosome LOH was analyzed for correlations with clinical and laboratory tumor characteristics as well as tumor growth characteristics.

RESULTS

Nine gastrinoma specimens (56%) had X-chromosome LOH, ranging from 6% to 23% at the 12 different loci studied. X-chromosome LOH was significantly associated with aggressive postoperative tumor growth, increased primary tumor size, and pancreatic primaries. In 6 tumor specimens, LOH occurred on Xp22.1-22.3 over a 28.4-centimorgan region.

CONCLUSIONS

X-chromosome LOH was common in gastrinoma specimens from female patients, and its presence was found to be a potentially useful molecular/genetic prognostic factor for aggressive growth.

Authors+Show Affiliations

Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15042671

Citation

Chen, Yuan-Jia, et al. "X-chromosome Loss of Heterozygosity Frequently Occurs in Gastrinomas and Is Correlated With Aggressive Tumor Growth." Cancer, vol. 100, no. 7, 2004, pp. 1379-87.
Chen YJ, Vortmeyer A, Zhuang Z, et al. X-chromosome loss of heterozygosity frequently occurs in gastrinomas and is correlated with aggressive tumor growth. Cancer. 2004;100(7):1379-87.
Chen, Y. J., Vortmeyer, A., Zhuang, Z., Gibril, F., & Jensen, R. T. (2004). X-chromosome loss of heterozygosity frequently occurs in gastrinomas and is correlated with aggressive tumor growth. Cancer, 100(7), 1379-87.
Chen YJ, et al. X-chromosome Loss of Heterozygosity Frequently Occurs in Gastrinomas and Is Correlated With Aggressive Tumor Growth. Cancer. 2004 Apr 1;100(7):1379-87. PubMed PMID: 15042671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - X-chromosome loss of heterozygosity frequently occurs in gastrinomas and is correlated with aggressive tumor growth. AU - Chen,Yuan-Jia, AU - Vortmeyer,Alexander, AU - Zhuang,Zhengping, AU - Gibril,Fathia, AU - Jensen,Robert T, PY - 2004/3/26/pubmed PY - 2004/5/7/medline PY - 2004/3/26/entrez SP - 1379 EP - 87 JF - Cancer JO - Cancer VL - 100 IS - 7 N2 - BACKGROUND: Recent studies have shown that tumor growth, rather than hormone overproduction, is the leading cause of death among patients with gastrinomas and other malignant gastrointestinal endocrine tumors. No patient/laboratory characteristics accurately predict which tumors will exhibit aggressive growth. Furthermore, little is known regarding the molecular pathogenesis of these tumors. X-chromosome loss of heterozygosity (LOH) occurs in some nonendocrine tumors, and its presence can be associated with aggressive growth/decreased survival. Data on X-chromosome LOH in gastrointestinal endocrine tumors are conflicting. Therefore, the purpose of the current study was to determine whether X-chromosome LOH occurred in gastrinomas and, if so, whether it was correlated with tumor growth, tumor behavior, and/or prognosis. METHODS: X chromosome allelotyping was performed using 12 microsatellite markers spaced throughout the chromosome using DNA from leukocytes and microdissected gastrinoma specimens from 16 female patients. The presence of X-chromosome LOH was analyzed for correlations with clinical and laboratory tumor characteristics as well as tumor growth characteristics. RESULTS: Nine gastrinoma specimens (56%) had X-chromosome LOH, ranging from 6% to 23% at the 12 different loci studied. X-chromosome LOH was significantly associated with aggressive postoperative tumor growth, increased primary tumor size, and pancreatic primaries. In 6 tumor specimens, LOH occurred on Xp22.1-22.3 over a 28.4-centimorgan region. CONCLUSIONS: X-chromosome LOH was common in gastrinoma specimens from female patients, and its presence was found to be a potentially useful molecular/genetic prognostic factor for aggressive growth. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15042671/X_chromosome_loss_of_heterozygosity_frequently_occurs_in_gastrinomas_and_is_correlated_with_aggressive_tumor_growth_ L2 - https://doi.org/10.1002/cncr.20104 DB - PRIME DP - Unbound Medicine ER -