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Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health Study.

Abstract

BACKGROUND

Reports on the relation between anthropometric variables (height, weight) and physical activity with ovarian cancer have been inconclusive. The objective of the current study was to extend investigation of potential associations in the Iowa Women's Health Study cohort.

METHODS

The relation between self-reported anthropometric variables and incident ovarian cancer was studied in a prospective cohort of women ages 55-69 years who were followed for 15 years. Two hundred twenty-three incident cases of epithelial ovarian cancer were identified by linkage to a cancer registry.

RESULTS

No association was found overall between ovarian cancer and height, but a positive association was observed for serous ovarian cancers (relative risk [RR], 1.86 for highest quartile vs. lowest quartile; 95% confidence interval [95% CI], 1.06-3.29). Although current body mass index (BMI) was not associated with ovarian cancer, a BMI > or =30 kg/m2 at age 18 years appeared to be associated positively with ovarian cancer (multivariate-adjusted RR, 1.83 for BMI > or =30 kg/m2 vs. BMI <25 kg/m2; 95% CI, 0.90-3.72), and this association was stronger after exclusion of the first 2 years of follow-up (RR, 2.15; 95% CI, 1.05-4.40). In a multivariate analysis, waist-to-hip ratio was associated with ovarian cancer (RR, 1.59 for highest quartile vs. lowest quartile; 95% CI, 1.05-2.40), but a linear dose response was not found. An index that combined the frequency and intensity of leisure-time physical activity was associated positively with ovarian cancer incidence (multivariate-adjusted RR, 1.42 for high activity vs. low activity; 95% CI, 1.03-1.97). This association was particularly strong for frequency of vigorous physical activity (multivariate-adjusted RR, 2.38 for >4 times per week vs. rarely/never; 95% CI, 1.29-4.38).

CONCLUSIONS

Anthropometric variables were not major risk factors for ovarian cancer in the cohort studied; however, high BMI in early adulthood and frequent and vigorous physical activity may increase the risk of ovarian cancer among postmenopausal women.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA.

    ,

    Source

    Cancer 100:7 2004 Apr 01 pg 1515-21

    MeSH

    Aged
    Body Constitution
    Body Height
    Body Mass Index
    Exercise
    Female
    Humans
    Incidence
    Iowa
    Middle Aged
    Ovarian Neoplasms
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15042687

    Citation

    Anderson, Jeffrey P., et al. "Anthropometric Variables, Physical Activity, and Incidence of Ovarian Cancer: the Iowa Women's Health Study." Cancer, vol. 100, no. 7, 2004, pp. 1515-21.
    Anderson JP, Ross JA, Folsom AR. Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health Study. Cancer. 2004;100(7):1515-21.
    Anderson, J. P., Ross, J. A., & Folsom, A. R. (2004). Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health Study. Cancer, 100(7), pp. 1515-21.
    Anderson JP, Ross JA, Folsom AR. Anthropometric Variables, Physical Activity, and Incidence of Ovarian Cancer: the Iowa Women's Health Study. Cancer. 2004 Apr 1;100(7):1515-21. PubMed PMID: 15042687.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health Study. AU - Anderson,Jeffrey P, AU - Ross,Julie A, AU - Folsom,Aaron R, PY - 2004/3/26/pubmed PY - 2004/5/7/medline PY - 2004/3/26/entrez SP - 1515 EP - 21 JF - Cancer JO - Cancer VL - 100 IS - 7 N2 - BACKGROUND: Reports on the relation between anthropometric variables (height, weight) and physical activity with ovarian cancer have been inconclusive. The objective of the current study was to extend investigation of potential associations in the Iowa Women's Health Study cohort. METHODS: The relation between self-reported anthropometric variables and incident ovarian cancer was studied in a prospective cohort of women ages 55-69 years who were followed for 15 years. Two hundred twenty-three incident cases of epithelial ovarian cancer were identified by linkage to a cancer registry. RESULTS: No association was found overall between ovarian cancer and height, but a positive association was observed for serous ovarian cancers (relative risk [RR], 1.86 for highest quartile vs. lowest quartile; 95% confidence interval [95% CI], 1.06-3.29). Although current body mass index (BMI) was not associated with ovarian cancer, a BMI > or =30 kg/m2 at age 18 years appeared to be associated positively with ovarian cancer (multivariate-adjusted RR, 1.83 for BMI > or =30 kg/m2 vs. BMI <25 kg/m2; 95% CI, 0.90-3.72), and this association was stronger after exclusion of the first 2 years of follow-up (RR, 2.15; 95% CI, 1.05-4.40). In a multivariate analysis, waist-to-hip ratio was associated with ovarian cancer (RR, 1.59 for highest quartile vs. lowest quartile; 95% CI, 1.05-2.40), but a linear dose response was not found. An index that combined the frequency and intensity of leisure-time physical activity was associated positively with ovarian cancer incidence (multivariate-adjusted RR, 1.42 for high activity vs. low activity; 95% CI, 1.03-1.97). This association was particularly strong for frequency of vigorous physical activity (multivariate-adjusted RR, 2.38 for >4 times per week vs. rarely/never; 95% CI, 1.29-4.38). CONCLUSIONS: Anthropometric variables were not major risk factors for ovarian cancer in the cohort studied; however, high BMI in early adulthood and frequent and vigorous physical activity may increase the risk of ovarian cancer among postmenopausal women. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15042687/Anthropometric_variables_physical_activity_and_incidence_of_ovarian_cancer:_The_Iowa_Women's_Health_Study_ L2 - https://doi.org/10.1002/cncr.20146 DB - PRIME DP - Unbound Medicine ER -