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Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects.
J Nat Prod. 2004 Mar; 67(3):432-6.JN

Abstract

Six new sesquiterpene coumarin derivatives, 2,3-dihydro-7-hydroxy-2R,3R-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]furo[3,2-c]coumarin (4), fukanefuromarin A (5), fukanefuromarin B (6), fukanefuromarin C (7), fukanefuromarin D (8), and fukanemarin A (9), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectral evidence, especially heteronuclear multiple-bond connectivity (HMBC), nuclear Overhauser exchange spectroscopy (NOESY), and high-resolution MS. An extract of F. fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).

Authors+Show Affiliations

Motai T
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
Daikonya A
No affiliation info available
Kitanaka S
No affiliation info available

MeSH

AnimalsChinaCoumarinsEnzyme InhibitorsFerulaInterferon-gammaLipopolysaccharidesMacrophagesMiceNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINitritesPlant RootsPlants, MedicinalRNA, MessengerSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15043424

Citation

Motai, Tsunetake, et al. "Sesquiterpene Coumarins From Ferula Fukanensis and Nitric Oxide Production Inhibitory Effects." Journal of Natural Products, vol. 67, no. 3, 2004, pp. 432-6.
Motai T, Daikonya A, Kitanaka S. Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects. J Nat Prod. 2004;67(3):432-6.
Motai, T., Daikonya, A., & Kitanaka, S. (2004). Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects. Journal of Natural Products, 67(3), 432-6.
Motai T, Daikonya A, Kitanaka S. Sesquiterpene Coumarins From Ferula Fukanensis and Nitric Oxide Production Inhibitory Effects. J Nat Prod. 2004;67(3):432-6. PubMed PMID: 15043424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects. AU - Motai,Tsunetake, AU - Daikonya,Akihiro, AU - Kitanaka,Susumu, PY - 2004/3/27/pubmed PY - 2004/5/15/medline PY - 2004/3/27/entrez SP - 432 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 67 IS - 3 N2 - Six new sesquiterpene coumarin derivatives, 2,3-dihydro-7-hydroxy-2R,3R-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]furo[3,2-c]coumarin (4), fukanefuromarin A (5), fukanefuromarin B (6), fukanefuromarin C (7), fukanefuromarin D (8), and fukanemarin A (9), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectral evidence, especially heteronuclear multiple-bond connectivity (HMBC), nuclear Overhauser exchange spectroscopy (NOESY), and high-resolution MS. An extract of F. fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma). SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15043424/Sesquiterpene_coumarins_from_Ferula_fukanensis_and_nitric_oxide_production_inhibitory_effects_ DB - PRIME DP - Unbound Medicine ER -