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Dietary calcium, sodium, phosphorus, and protein and bone metabolism in elderly Japanese women: a pilot study using the duplicate portion sampling method.
Nutrition 2004; 20(4):340-5N

Abstract

OBJECTIVES

Associations between dietary factors and bone metabolism in Asians have not been thoroughly investigated. The purpose of this study was to determine the effect of dietary intake of calcium (Ca), phosphorus (P), sodium (Na), and protein on bone metabolism in elderly Japanese women by the duplicate portion sampling method.

METHODS

The subjects were 43 healthy female volunteers (mean age, 68.3 y; standard deviation, 6.8). Dietary nutrients were directly determined by using a 24-h duplicate meal portion. Serum osteocalcin and bone alkaline phosphatase and urinary deoxypyridinoline (DPD) and type I collagen cross-linked N-telopeptides (NTX-I) were measured as markers of bone turnover. Hormones related to bone metabolism, including serum 25-hydroxyvitamin D(3), 1,25-dihydroxyvitamin D(3), and intact parathyroid hormone also were determined. Urinary parameters were corrected for urinary creatinine concentration.

RESULTS

The mean (standard deviation) daily dietary intakes of Ca, P, Na, and protein were 660 (195) mg, 996 (208) mg, 4080 (1142) mg, and 63.9 (15.5) g, respectively. Dietary Ca was negatively correlated with urinary DPD (r = -0.417, P = 0.005) and NTX-I (r = -0.324, P = 0.034), and dietary P was negatively correlated with urinary DPD (r = -0.307, P = 0.045). Multiple regression analysis showed that only dietary Ca was associated with urinary DPD and NTX-I. Dietary Ca intake was significantly associated with bone resorption markers, but no other dietary factors were associated with any of the biochemical markers.

CONCLUSION

The major factor having an adverse effect on the bone health of the elderly Japanese women is low Ca intake and not other dietary minerals or protein.

Authors+Show Affiliations

Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15043848

Citation

Nakamura, Kazutoshi, et al. "Dietary Calcium, Sodium, Phosphorus, and Protein and Bone Metabolism in Elderly Japanese Women: a Pilot Study Using the Duplicate Portion Sampling Method." Nutrition (Burbank, Los Angeles County, Calif.), vol. 20, no. 4, 2004, pp. 340-5.
Nakamura K, Hori Y, Nashimoto M, et al. Dietary calcium, sodium, phosphorus, and protein and bone metabolism in elderly Japanese women: a pilot study using the duplicate portion sampling method. Nutrition. 2004;20(4):340-5.
Nakamura, K., Hori, Y., Nashimoto, M., Okuda, Y., Miyazaki, H., Kasai, Y., & Yamamoto, M. (2004). Dietary calcium, sodium, phosphorus, and protein and bone metabolism in elderly Japanese women: a pilot study using the duplicate portion sampling method. Nutrition (Burbank, Los Angeles County, Calif.), 20(4), pp. 340-5.
Nakamura K, et al. Dietary Calcium, Sodium, Phosphorus, and Protein and Bone Metabolism in Elderly Japanese Women: a Pilot Study Using the Duplicate Portion Sampling Method. Nutrition. 2004;20(4):340-5. PubMed PMID: 15043848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary calcium, sodium, phosphorus, and protein and bone metabolism in elderly Japanese women: a pilot study using the duplicate portion sampling method. AU - Nakamura,Kazutoshi, AU - Hori,Yasushi, AU - Nashimoto,Mitsue, AU - Okuda,Yoko, AU - Miyazaki,Hideo, AU - Kasai,Yasunori, AU - Yamamoto,Masaharu, PY - 2004/3/27/pubmed PY - 2005/3/11/medline PY - 2004/3/27/entrez SP - 340 EP - 5 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 20 IS - 4 N2 - OBJECTIVES: Associations between dietary factors and bone metabolism in Asians have not been thoroughly investigated. The purpose of this study was to determine the effect of dietary intake of calcium (Ca), phosphorus (P), sodium (Na), and protein on bone metabolism in elderly Japanese women by the duplicate portion sampling method. METHODS: The subjects were 43 healthy female volunteers (mean age, 68.3 y; standard deviation, 6.8). Dietary nutrients were directly determined by using a 24-h duplicate meal portion. Serum osteocalcin and bone alkaline phosphatase and urinary deoxypyridinoline (DPD) and type I collagen cross-linked N-telopeptides (NTX-I) were measured as markers of bone turnover. Hormones related to bone metabolism, including serum 25-hydroxyvitamin D(3), 1,25-dihydroxyvitamin D(3), and intact parathyroid hormone also were determined. Urinary parameters were corrected for urinary creatinine concentration. RESULTS: The mean (standard deviation) daily dietary intakes of Ca, P, Na, and protein were 660 (195) mg, 996 (208) mg, 4080 (1142) mg, and 63.9 (15.5) g, respectively. Dietary Ca was negatively correlated with urinary DPD (r = -0.417, P = 0.005) and NTX-I (r = -0.324, P = 0.034), and dietary P was negatively correlated with urinary DPD (r = -0.307, P = 0.045). Multiple regression analysis showed that only dietary Ca was associated with urinary DPD and NTX-I. Dietary Ca intake was significantly associated with bone resorption markers, but no other dietary factors were associated with any of the biochemical markers. CONCLUSION: The major factor having an adverse effect on the bone health of the elderly Japanese women is low Ca intake and not other dietary minerals or protein. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/15043848/Dietary_calcium_sodium_phosphorus_and_protein_and_bone_metabolism_in_elderly_Japanese_women:_a_pilot_study_using_the_duplicate_portion_sampling_method_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899900703003022 DB - PRIME DP - Unbound Medicine ER -