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Rabies and other lyssavirus diseases.
Lancet. 2004 Mar 20; 363(9413):959-69.Lct

Abstract

The full scale of the global burden of human rabies is unknown, owing to inadequate surveillance of this fatal disease. However, the terror of hydrophobia, a cardinal symptom of rabies encephalitis, is suffered by tens of thousands of people each year. The recent discovery of enzootic European bat lyssavirus infection in the UK is indicative of our expanding awareness of the Lyssavirus genus. The main mammalian vector species vary geographically, so the health problems created by the lyssaviruses and their management differ throughout the world. The methods by which these neurotropic viruses hijack neurophysiological mechanisms while evading immune surveillance is beginning to be unravelled by, for example, studies of molecular motor transport systems. Meanwhile, enormous challenges remain in the control of animal rabies and the provision of accessible, appropriate human prophylaxis worldwide.

Authors+Show Affiliations

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK. mary.warrell@ndm.ox.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15043965

Citation

Warrell, M J., and D A. Warrell. "Rabies and Other Lyssavirus Diseases." Lancet (London, England), vol. 363, no. 9413, 2004, pp. 959-69.
Warrell MJ, Warrell DA. Rabies and other lyssavirus diseases. Lancet. 2004;363(9413):959-69.
Warrell, M. J., & Warrell, D. A. (2004). Rabies and other lyssavirus diseases. Lancet (London, England), 363(9413), 959-69.
Warrell MJ, Warrell DA. Rabies and Other Lyssavirus Diseases. Lancet. 2004 Mar 20;363(9413):959-69. PubMed PMID: 15043965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rabies and other lyssavirus diseases. AU - Warrell,M J, AU - Warrell,D A, PY - 2004/3/27/pubmed PY - 2004/4/28/medline PY - 2004/3/27/entrez SP - 959 EP - 69 JF - Lancet (London, England) JO - Lancet VL - 363 IS - 9413 N2 - The full scale of the global burden of human rabies is unknown, owing to inadequate surveillance of this fatal disease. However, the terror of hydrophobia, a cardinal symptom of rabies encephalitis, is suffered by tens of thousands of people each year. The recent discovery of enzootic European bat lyssavirus infection in the UK is indicative of our expanding awareness of the Lyssavirus genus. The main mammalian vector species vary geographically, so the health problems created by the lyssaviruses and their management differ throughout the world. The methods by which these neurotropic viruses hijack neurophysiological mechanisms while evading immune surveillance is beginning to be unravelled by, for example, studies of molecular motor transport systems. Meanwhile, enormous challenges remain in the control of animal rabies and the provision of accessible, appropriate human prophylaxis worldwide. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/15043965/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140673604157929 DB - PRIME DP - Unbound Medicine ER -