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Oxygen sensing and oxidant/redox-related pathways.
Biochem Biophys Res Commun. 2004 Apr 16; 316(4):969-77.BB

Abstract

What is the nature of the oxygen sensor(s) and how do organisms sense variations in oxygen? A progressive rise of oxidative stress due to the altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription. Dynamic changes in oxygen homeostasis and its close association with redox equilibrium, therefore, constitute a signaling mechanism for the expression/activation of oxygenes. This variation subsequently regulates the compartmentalization and functioning of HIF-1alpha and NF-kappaB. In addition, oxygen-evoked regulation of HIF-1alpha and NF-kappaB is closely coupled with intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation). Interestingly, are these particular transcription factors potential oxygen sensors? The basic components of the intracellular oxidative/redox machinery and its crucial regulation of oxygen- and redox-sensitive transcription factors may help understand the network of oxygen sensing mechanisms and redox-related pathways.

Authors+Show Affiliations

Severinghaus-Radiometer Research Laboratories, University of California, San Francisco, CA, USA. johnjhaddad@yahoo.co.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15044079

Citation

Haddad, John J.. "Oxygen Sensing and Oxidant/redox-related Pathways." Biochemical and Biophysical Research Communications, vol. 316, no. 4, 2004, pp. 969-77.
Haddad JJ. Oxygen sensing and oxidant/redox-related pathways. Biochem Biophys Res Commun. 2004;316(4):969-77.
Haddad, J. J. (2004). Oxygen sensing and oxidant/redox-related pathways. Biochemical and Biophysical Research Communications, 316(4), 969-77.
Haddad JJ. Oxygen Sensing and Oxidant/redox-related Pathways. Biochem Biophys Res Commun. 2004 Apr 16;316(4):969-77. PubMed PMID: 15044079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygen sensing and oxidant/redox-related pathways. A1 - Haddad,John J, PY - 2004/02/24/received PY - 2004/3/27/pubmed PY - 2004/5/22/medline PY - 2004/3/27/entrez SP - 969 EP - 77 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 316 IS - 4 N2 - What is the nature of the oxygen sensor(s) and how do organisms sense variations in oxygen? A progressive rise of oxidative stress due to the altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription. Dynamic changes in oxygen homeostasis and its close association with redox equilibrium, therefore, constitute a signaling mechanism for the expression/activation of oxygenes. This variation subsequently regulates the compartmentalization and functioning of HIF-1alpha and NF-kappaB. In addition, oxygen-evoked regulation of HIF-1alpha and NF-kappaB is closely coupled with intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation). Interestingly, are these particular transcription factors potential oxygen sensors? The basic components of the intracellular oxidative/redox machinery and its crucial regulation of oxygen- and redox-sensitive transcription factors may help understand the network of oxygen sensing mechanisms and redox-related pathways. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/15044079/Oxygen_sensing_and_oxidant/redox_related_pathways_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006291X04004498 DB - PRIME DP - Unbound Medicine ER -