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Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells.
Biochem Biophys Res Commun. 2004 Apr 16; 316(4):1065-72.BB

Abstract

Infection of epithelial cells by the microbial pathogen Helicobacter pylori leads to activation of the transcription factor nuclear factor kappaB (NF-kappaB), the induction of pro-inflammatory cytokine/chemokine genes, and the motogenic response (cell scattering). Here we report that H. pylori-induced NF-kappaB activation and the subsequent release of interleukin 8 (IL-8) are inhibited by curcumin (diferuloylmethane), a yellow pigment in turmeric (Curcuma longa L.). Our results demonstrate that curcumin inhibits IkappaBalpha degradation, the activity of IkappaB kinases alpha and beta (IKKalpha and beta), and NF-kappaB DNA-binding. The mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases 1/2 (ERK1/2) and p38, which are also activated by H. pylori infection, were not inhibited by curcumin. Further, the H. pylori-induced motogenic response was blocked by curcumin. We conclude that curcumin, due to inhibition of NF-kappaB activation and cell scattering, should be considered as a potential therapeutic agent effective against pathogenic processes initiated by H. pylori infection.

Authors+Show Affiliations

Institute of Experimental Internal Medicine, Otto-von-Guericke-University, Leipziger Str. 44, Magdeburg 39120, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15044093

Citation

Foryst-Ludwig, Anna, et al. "Curcumin Blocks NF-kappaB and the Motogenic Response in Helicobacter Pylori-infected Epithelial Cells." Biochemical and Biophysical Research Communications, vol. 316, no. 4, 2004, pp. 1065-72.
Foryst-Ludwig A, Neumann M, Schneider-Brachert W, et al. Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun. 2004;316(4):1065-72.
Foryst-Ludwig, A., Neumann, M., Schneider-Brachert, W., & Naumann, M. (2004). Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochemical and Biophysical Research Communications, 316(4), 1065-72.
Foryst-Ludwig A, et al. Curcumin Blocks NF-kappaB and the Motogenic Response in Helicobacter Pylori-infected Epithelial Cells. Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PubMed PMID: 15044093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. AU - Foryst-Ludwig,Anna, AU - Neumann,Manfred, AU - Schneider-Brachert,Wulf, AU - Naumann,Michael, PY - 2003/12/22/received PY - 2004/3/27/pubmed PY - 2004/5/22/medline PY - 2004/3/27/entrez SP - 1065 EP - 72 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 316 IS - 4 N2 - Infection of epithelial cells by the microbial pathogen Helicobacter pylori leads to activation of the transcription factor nuclear factor kappaB (NF-kappaB), the induction of pro-inflammatory cytokine/chemokine genes, and the motogenic response (cell scattering). Here we report that H. pylori-induced NF-kappaB activation and the subsequent release of interleukin 8 (IL-8) are inhibited by curcumin (diferuloylmethane), a yellow pigment in turmeric (Curcuma longa L.). Our results demonstrate that curcumin inhibits IkappaBalpha degradation, the activity of IkappaB kinases alpha and beta (IKKalpha and beta), and NF-kappaB DNA-binding. The mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases 1/2 (ERK1/2) and p38, which are also activated by H. pylori infection, were not inhibited by curcumin. Further, the H. pylori-induced motogenic response was blocked by curcumin. We conclude that curcumin, due to inhibition of NF-kappaB activation and cell scattering, should be considered as a potential therapeutic agent effective against pathogenic processes initiated by H. pylori infection. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/15044093/Curcumin_blocks_NF_kappaB_and_the_motogenic_response_in_Helicobacter_pylori_infected_epithelial_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006291X04004437 DB - PRIME DP - Unbound Medicine ER -