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Hyperadiponectinemia in newborns: relationship with leptin levels and birth weight.
Obes Res 2004; 12(3):521-4OR

Abstract

OBJECTIVE

Adiponectin is the only adipose-specific hormone that, despite its exclusive production by adipose tissue, is reduced in obesity and is inversely correlated with leptin levels in adults. The aim of this study was to evaluate the adiponectin concentration in umbilical cord blood at different gestational ages and to investigate its possible associations with leptin levels and birth weight.

RESEARCH METHODS AND PROCEDURES

Umbilical cord blood was obtained from 132 newborns (male = 65, female = 67, gestational age: 35 to 42 weeks). The anthropometric variables of the newborns studied were birth weight, birth length, body weight/body length, and ponderal index. Adiponectin, insulin, and leptin levels were measured by radioimmunoassay methods.

RESULTS

Adiponectin levels in males were not different from those in females (24.10 +/- 0.81 vs. 25.62 +/- 0.84 micro g/mL, p = 0.280). Adiponectin concentrations were positively correlated with birth weight (p < 0.05), birth length (p < 0.05), body weight/body length (p < 0.05), gestational age (p < 0.01), and leptin levels (p < 0.01).

DISCUSSION

These findings indicate that adiponectin is present in umbilical cord blood after 35 to 42 weeks of gestation, with higher levels than those usually found in adults, no gender differences, and a positive correlation with birth weight and leptin. These results suggest that not only could neonatal hyperadiponectinemia be associated with the increase of adiponectin production by fetal adipose tissue but also with a possible reduction in an unknown mechanism related to the suppression of adiponectin observed in adults.

Authors+Show Affiliations

Department of Pediatrics, University of Campinas, São Paulo, Brazil. doctorpardo@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15044670

Citation

Pardo, Inês M C G., et al. "Hyperadiponectinemia in Newborns: Relationship With Leptin Levels and Birth Weight." Obesity Research, vol. 12, no. 3, 2004, pp. 521-4.
Pardo IM, Geloneze B, Tambascia MA, et al. Hyperadiponectinemia in newborns: relationship with leptin levels and birth weight. Obes Res. 2004;12(3):521-4.
Pardo, I. M., Geloneze, B., Tambascia, M. A., & Barros-Filho, A. A. (2004). Hyperadiponectinemia in newborns: relationship with leptin levels and birth weight. Obesity Research, 12(3), pp. 521-4.
Pardo IM, et al. Hyperadiponectinemia in Newborns: Relationship With Leptin Levels and Birth Weight. Obes Res. 2004;12(3):521-4. PubMed PMID: 15044670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperadiponectinemia in newborns: relationship with leptin levels and birth weight. AU - Pardo,Inês M C G, AU - Geloneze,Bruno, AU - Tambascia,Marcos A, AU - Barros-Filho,Antonio A, PY - 2004/3/27/pubmed PY - 2004/7/9/medline PY - 2004/3/27/entrez SP - 521 EP - 4 JF - Obesity research JO - Obes. Res. VL - 12 IS - 3 N2 - OBJECTIVE: Adiponectin is the only adipose-specific hormone that, despite its exclusive production by adipose tissue, is reduced in obesity and is inversely correlated with leptin levels in adults. The aim of this study was to evaluate the adiponectin concentration in umbilical cord blood at different gestational ages and to investigate its possible associations with leptin levels and birth weight. RESEARCH METHODS AND PROCEDURES: Umbilical cord blood was obtained from 132 newborns (male = 65, female = 67, gestational age: 35 to 42 weeks). The anthropometric variables of the newborns studied were birth weight, birth length, body weight/body length, and ponderal index. Adiponectin, insulin, and leptin levels were measured by radioimmunoassay methods. RESULTS: Adiponectin levels in males were not different from those in females (24.10 +/- 0.81 vs. 25.62 +/- 0.84 micro g/mL, p = 0.280). Adiponectin concentrations were positively correlated with birth weight (p < 0.05), birth length (p < 0.05), body weight/body length (p < 0.05), gestational age (p < 0.01), and leptin levels (p < 0.01). DISCUSSION: These findings indicate that adiponectin is present in umbilical cord blood after 35 to 42 weeks of gestation, with higher levels than those usually found in adults, no gender differences, and a positive correlation with birth weight and leptin. These results suggest that not only could neonatal hyperadiponectinemia be associated with the increase of adiponectin production by fetal adipose tissue but also with a possible reduction in an unknown mechanism related to the suppression of adiponectin observed in adults. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15044670/Hyperadiponectinemia_in_newborns:_relationship_with_leptin_levels_and_birth_weight_ L2 - https://doi.org/10.1038/oby.2004.59 DB - PRIME DP - Unbound Medicine ER -