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Effects of mosquito genes on Plasmodium development.
Science. 2004 Mar 26; 303(5666):2030-2.Sci

Abstract

Malaria parasites must complete a complex developmental cycle in an Anopheles mosquito vector before transmission to a vertebrate host. Sexual development of the parasite in the midgut is initiated in the lumen immediately after the mosquito ingests infected blood, and the resulting ookinetes must traverse the surrounding epithelial layer before transforming into oocysts. The innate immune system of the mosquito is activated during midgut invasion, but to date, no evidence has been published identifying mosquito immune genes that affect parasite development. Here, we show by gene silencing that an Anopheles gambiae leucine rich-repeat protein acts as an antagonist and two C-type lectines act as protective agonists on the development of Plasmodium ookinetes to oocysts.

Authors+Show Affiliations

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15044804

Citation

Osta, Mike A., et al. "Effects of Mosquito Genes On Plasmodium Development." Science (New York, N.Y.), vol. 303, no. 5666, 2004, pp. 2030-2.
Osta MA, Christophides GK, Kafatos FC. Effects of mosquito genes on Plasmodium development. Science. 2004;303(5666):2030-2.
Osta, M. A., Christophides, G. K., & Kafatos, F. C. (2004). Effects of mosquito genes on Plasmodium development. Science (New York, N.Y.), 303(5666), 2030-2.
Osta MA, Christophides GK, Kafatos FC. Effects of Mosquito Genes On Plasmodium Development. Science. 2004 Mar 26;303(5666):2030-2. PubMed PMID: 15044804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of mosquito genes on Plasmodium development. AU - Osta,Mike A, AU - Christophides,George K, AU - Kafatos,Fotis C, PY - 2004/3/27/pubmed PY - 2004/4/23/medline PY - 2004/3/27/entrez SP - 2030 EP - 2 JF - Science (New York, N.Y.) JO - Science VL - 303 IS - 5666 N2 - Malaria parasites must complete a complex developmental cycle in an Anopheles mosquito vector before transmission to a vertebrate host. Sexual development of the parasite in the midgut is initiated in the lumen immediately after the mosquito ingests infected blood, and the resulting ookinetes must traverse the surrounding epithelial layer before transforming into oocysts. The innate immune system of the mosquito is activated during midgut invasion, but to date, no evidence has been published identifying mosquito immune genes that affect parasite development. Here, we show by gene silencing that an Anopheles gambiae leucine rich-repeat protein acts as an antagonist and two C-type lectines act as protective agonists on the development of Plasmodium ookinetes to oocysts. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/15044804/Effects_of_mosquito_genes_on_Plasmodium_development_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=15044804 DB - PRIME DP - Unbound Medicine ER -