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Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
Neuron. 2004 Mar 25; 41(6):849-57.N

Abstract

Six members of the mammalian transient receptor potential (TRP) ion channels respond to varied temperature thresholds. The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively. The burning and cooling perception of capsaicin and menthol demonstrate that these ion channels mediate thermosensation. We show that, in addition to noxious cold, pungent natural compounds present in cinnamon oil, wintergreen oil, clove oil, mustard oil, and ginger all activate TRPA1 (ANKTM1). Bradykinin, an inflammatory peptide acting through its G protein-coupled receptor, also activates TRPA1. We further show that phospholipase C is an important signaling component for TRPA1 activation. Cinnamaldehyde, the most specific TRPA1 activator, excites a subset of sensory neurons highly enriched in cold-sensitive neurons and elicits nociceptive behavior in mice. Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.

Authors+Show Affiliations

Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15046718

Citation

Bandell, Michael, et al. "Noxious Cold Ion Channel TRPA1 Is Activated By Pungent Compounds and Bradykinin." Neuron, vol. 41, no. 6, 2004, pp. 849-57.
Bandell M, Story GM, Hwang SW, et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004;41(6):849-57.
Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004). Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron, 41(6), 849-57.
Bandell M, et al. Noxious Cold Ion Channel TRPA1 Is Activated By Pungent Compounds and Bradykinin. Neuron. 2004 Mar 25;41(6):849-57. PubMed PMID: 15046718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. AU - Bandell,Michael, AU - Story,Gina M, AU - Hwang,Sun Wook, AU - Viswanath,Veena, AU - Eid,Samer R, AU - Petrus,Matt J, AU - Earley,Taryn J, AU - Patapoutian,Ardem, PY - 2004/01/27/received PY - 2004/02/18/revised PY - 2004/03/04/accepted PY - 2004/3/30/pubmed PY - 2004/5/21/medline PY - 2004/3/30/entrez SP - 849 EP - 57 JF - Neuron JO - Neuron VL - 41 IS - 6 N2 - Six members of the mammalian transient receptor potential (TRP) ion channels respond to varied temperature thresholds. The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively. The burning and cooling perception of capsaicin and menthol demonstrate that these ion channels mediate thermosensation. We show that, in addition to noxious cold, pungent natural compounds present in cinnamon oil, wintergreen oil, clove oil, mustard oil, and ginger all activate TRPA1 (ANKTM1). Bradykinin, an inflammatory peptide acting through its G protein-coupled receptor, also activates TRPA1. We further show that phospholipase C is an important signaling component for TRPA1 activation. Cinnamaldehyde, the most specific TRPA1 activator, excites a subset of sensory neurons highly enriched in cold-sensitive neurons and elicits nociceptive behavior in mice. Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain. SN - 0896-6273 UR - https://www.unboundmedicine.com/medline/citation/15046718/Noxious_cold_ion_channel_TRPA1_is_activated_by_pungent_compounds_and_bradykinin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896627304001503 DB - PRIME DP - Unbound Medicine ER -